Finasteride and dry eye

1. Finasteride induced dry eye in rats

Singh S, Moksha L, Sharma N, Titiyal JS, Biswas NR, Velpandian T. Development and evaluation of animal models for sex steroid deficient dry eye. J Pharmacol Toxicol Methods. 2014;70(1):29–34. doi:10.1016/j.vascn.2014.03.004

2. Finasteride-induced dry eye in female rats results from inflammation of lacrimal glands

Li K, Zhang C, Yang Z, Wang Y, Si H. Evaluation of a novel dry eye model induced by oral administration of finasteride. Mol Med Rep. 2017;16(6):8763–8770. doi:10.3892/mmr.2017.7754

3. Study explores androgens as key factor in Sjögren’s Syndrome, and androgens as a potential treatment

Sullivan DA, Wickham LA, Rocha EM, et al. Androgens and dry eye in Sjögren’s syndrome. Ann N Y Acad Sci. 1999;876:312–324. doi:10.1111/j.1749-6632.1999.tb07656.x

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extremely interesting! thanks for sharing this

very important exert from the first paper
“subjecting 60days post ovariectomy rats to finasteride challenge did not show any further decrease in tear flow. Gene expression analysis also revealed a significant downregulation of sex steroid receptors in ocular tissues after ovariectomy and finasteride challenge.”

Seems the rats AR was actually downregulated

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