Found this interesting… a doctor claiming 5AR inhibitors can cause acquired androgen insensitivity.
David J Handelsman MB BS, FRACP, PhD Director, ANZAC Research Institute & Department of Andrology, Concord Hospital, Professor of Reproductive Endocrinology & Andrology, University of Sydney,Sydney, NSW 2139, Australia
Updated 20 December 2008
endotext.org/male/male2/male2.htm
Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5α reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
In addition, drugs may have physiological effects or pharmacological actions that oppose various steps in androgen action such as LH and FSH suppression by estrogens or progestins or that cause an increase in circulating SHBG which may influence testosterone transfer from blood into tissues to produce a functional phenocopy of androgen insensitivity.