https://www.mdpi.com/2218-273X/15/7/1044
How would one ever get in a human trial of this?
I have every symptom mentioned here…
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I think the better question is where you find people crazy enough to participate knowing what could happen if they browsed around here for just 10 minutes?
On a serious note what I find interesting here is that it’s almost like some distinct flavor of ME/CFS, just look at those differences in metabolites and how all but 3 increase and the rest fall into the black never mind how multi layered this is. It’s no wonder what anyone tries most things seem to backfire with so much going on with these post-drug conditions at once. As per usual it seems it needs to be attacked before anything happens during the withdrawal phase. So it involves what appears to be from what I can take from this some specific metabolic waste overload that has some associated with some glutamate metabolite and glutaric acid (but why could play a huge role in solving the issue and vastly influence how you’d do this)but judging by the acidemia state related you could try carnitine to ease the overload effects), a gut inflammation problem with a focus on the colon and microbiome in general, a gut and BBB integrity loop problem associated with the elevations, and of course the main effects of the drug itself that cause the chain reaction in the first place that based on this appears to be a withdrawal that can occur (withdrawals can be complex are more than cold turkey or gradual reduction based too, there is even between dose withdrawal with certain compounds that can occur). I think the best way to tackle the situation in layers is by finding out what in the loop is causing certain problems specifically and repairing them piece by piece. Which I suspect is how I over time got out by dumb luck in doing so with micro-managing the situation.
It’s interesting that they link frequent urination to hypothalamic inflammation.
That’s been my worst PFS side effect over the years.