Just to chime in, Allopregnanolone seems to be excretioned through both urine and feces.
So it might just be that the people with high urine allopregnanolone have a lower concentration in feces. So in theory they might be high or low, in total.
Just to chime in, Allopregnanolone seems to be excretioned through both urine and feces.
So it might just be that the people with high urine allopregnanolone have a lower concentration in feces. So in theory they might be high or low, in total.
Thank you for trying out new (possible) treatments and sharing this with us. Finding 1,4-Butanediol should be the easy part, i think you can get it from ebay. Even if this protocol doesn’t work, that’s another angle we can rule out. Please keep us updated if you try it.
Interesting
We will need an equal amount of non PFS people to get the urine ZRT test to have a better idea if high Allopregnanolone and 3a-diol in the urine is exclusive to PFS people
In my opinion if we end up with 7-10 PFS people with high Allopregnanolone and 3a-diol in the urine and 7-10 non people that don’t have high Allopregnanolone and 3a-diol in the urine then I think this is important
Same thing with high T and DHT in the urine . If it’s exclusive to PFS people I don’t think it should be ignored
Please create thread for urine test topic
Don’t see any on eBay and probably not safe source anyway
A little off topic but what about microdosing shrooms? I was going to try them but I could not find any here in Turkey and then forget about them. On reddit there is a huge group where people cured many issues with microdosing shrooms. Mainly depression. But also migraines, anxiety, psychological issues etc. It seems to fix something in the brain for many people.
Just mentioning because we talk about GHB.
The internet is full of excitement for and stories about seductive magical cures for everything. I prefer to stick with things that actually have direct scientific basis for addressing our condition.
I have been doing this for a while and can attest to this: it does seem to work for the mental side of things.
I have to do it . I’m going to create the thread and post everyone’s results. I’m just so busy and it’s so much work so it’s taking me a while to make time for it
Have you seen the new straight Allopregnanolone product being sold from the lab that was selling 5a-DHP? I haven’t read the whole ray peat Allopregnanolone product trials thread yet because I have been really busy with other non PFS stuff. But that’s what you are trying to do right ? Increase Alleopreg?
ordered today, will test soon.
I’ve taken IdeaLab’s AlloP (orally bioavailable Allopregnanolone) for two days so far (2mg/2 drops, sublingual, 10mins, morning). Sometimes I’ll take an additional 1-2mg in the afternoon/evening too after the first dose starts to wear off. It’s probably too soon to say anything definitive yet, but so far it appears to be helping with my symptoms! Unrelated to taking AlloP, I’ve also been waking up 6:30-7 instead of 8-9 and eating while getting outdoor light for 30min within the first hour after waking. This, in addition to entraining my circadian rhythm and promoting a natural morning cortisol spike, also seems to be helping with my symptoms in general too.
Improvements I’ve noticed after 2 days:
Remaining symptoms:
Thoughts/Concerns:
Cautionary Studies:
Update:
Too much AlloP over time makes my symptoms worse, especially anxiety. It may build up in one’s body (1-2 day half life I believe) so daily dosing isn’t necessary.
On the third day, 2mg morning 3mg evening made me more dulled and anxious after the evening dose. I took only 1mg this morning which also made me anxious, so I might try a day off tomorrow and see if the anxiety subsides.
edit:
strangely a 4mg nicotine lozange immediately seemed to quell my anxiety after the 1mg dose.
Allopregnanolone half life is about 9 hours I believe.
I was quoting:
“When it is dissolved in tocopherols, the half life is probably the same as the half life of the tocopherol molecule, which is up to 48 hours in most in-vivo models.”
Post in thread ‘AlloP - Liquid Allopregnanolone For Lab/R&D’ https://raypeatforum.com/community/threads/allop-liquid-allopregnanolone-for-lab-r-d.41055/post-670030
Unless they’re chemically bonded I’d really doubt it.
Took a Tribulus this morning and within 1-2 hours, I actually felt it working! After taking the AlloP for a few days and waiting 3 months post-quitting, I think I might finally be responding to proandrogenic supplements again (ARs may be starting to return to baseline sensitivity). When I took Tribulus in the 1-2 month time frame post-quitting Fin (high protodioscin vemoherb brand), it actually made my symptoms worse, so this is definitely an encouraging sign.
Tribulus synergized even more with AlloP on the second day.
Took a single milligram of AlloP orally (not sublingually), one tribulus capsule, and my usual 200 mg caffeine and 5000 iu D3 an hour after waking. Also I know some are opposed to nicotine use even in gum or lozenge form due to it’s potential for causing excessive sympathetic stimulation (e.g. sweaty palms, high blood pressure/pounding heart). However, when I use a 4 mg nicotine lozenge split in half with a half on either cheek (faster absorbtion and higher peak than unsplit), the synergy and improvement in symptoms is even stronger.
Third day, the synergy between 1 capsule of Tribulus and 1mg alloP in the morning abruptly stopped. I no longer felt the effects of Tribulus (back to insensitive AR state) and the cognitive symptoms (anxiety, dissociation, and memory impairment) returned despite alloP, so I will stop taking both for a few days-weeks before trying anything again. I think I’m right at the transition period 3-4 months after quitting where the ARs are just beginning to respond normally to androgens on there own again but can still quickly revert and shut down/desensitize if overwhelmed through too much consecutive Tribulus etc.
This thread brought something new and somehow got transformed into being about the same herbs and forum chemicals people have been trying and failing with for over a decade.
Fair point regarding Tribulus. But isn’t taking orally bioavailable pure allopregnanolone as @5-alpha-victim linked a more direct way to increase its levels than with “Etifoxine”?