I don’t find an official source explaining why estrogens increase when under finastéride.
There is more testo. to transform in estrogen by the aromatase,ok.
but i thought i had also seen that DHT and its metabolites were regulating aromatase activity, so that when DHT drops
aromatase is even more active…
it si for example said in this article, but the source is not that good. bodybuilding.com/fun/reform8.htm
but apart from that i don’t find good source.
what is the mechanisms which make estrogens increase?
can we say dht somehow inhibits/or regulate aromatase?
blasé
this is very good question. I myself have been thinking why our bodies are converting more to Estrogen.
We have become like alcoholic people who get almost the same symptoms.they get gyno too .
I spoke to a doctor (a fried of my friend). after hearing me he asked about my liver tests (which are fine, including CT scan).He said that liver cirhosis is the main cause of estrogen issues in alchoholic people, then again it takes years to go to that stage. So what is causing fast estrogen conversion in our case? Maybe some subclnical liver damage?
It is a shame even 11 years after we are still at zero point.
liver damage?
it is interesting as my GP who is also oriented antia age stuff told me interesting stuff about liver and
leaky guts syndrom.
I showed him my inflammation ultra sound, he said may be it was persistant because of gut or liver issue.
did you look my recent post viewtopic.php?f=27&t=5550&start=40
Accutan has caused auto immune hepatitis. I don’t know if this caused PFS too?
I stress every body reading this, please search Accutane sufferes who got AIH+sexual sides.
if we can find any such post , I think this may be our smoking gun.
Can anyone recommend a good liver cleanse? I agree we have some connection to liver - fin raises estrogen and the liver helps rid our bodies of excess estrogen. I’d like to lower my estrogen level naturally rather than through pills. Have to think if we cleanse the liver it could help in this regard. However, mnay liver cleanses contain milk thistle which we should stay away from. Chineses bitters I have heard good and bad.
Has anyone had success and with which products. Thanks
stay away from any so called herbal stuff, it will do more harm than good. there is no such thing as liver cleans.This is all B.S.
we don’t know yet the exact cause but looks like anti bodies are playing some role, but again not proved yet.
may be true but several on the boards have had imrpovements using liver cleanses.
If fin continually raises estrogen and eventually our body could not excrete as efficently through the liver then we would have a T/E imbalance - right?
My E is continually elevated - the liver is very good at healing why would this have no effect?
One theory I read said that when fin blocked/damaged the 5ar2 gene, the high testosterone level in us from masturbating all the time triggered the liver to create excess aromatase to convert the excess testosterone in our blood to estrogen… so the liver needs to be cleansed and detoxified for it to release normal amounts of aromatase
Finasteride is documented to shift the androgen/estrogen ratio to be in favor of estrogen because it inhibits DHT. Testosterone which would normally be metabolized to DHT cannot, therefore it aromatizes to estrogen instead. Hence the warning for gynecomastia and male breast cancer on the packaging for Finasteride.
This has nothing to do with “masturbating all the time”, if anything taking Finasteride should decrease one’s libido, not heighten it. If you were fine before Finasteride and masturbated excessively without issues, that should tell you something – that it was a result of Finasteride skewing your hormones that has caused your estrogenic side effects (documented in clinical studies and on label), NOT “masturbation” before or after the drug.
I never said finasteride increases anyone’s libido. It’s not in human’s biology to masturbate every single day. The fact of the matter is that masturbation increases testosterone. So when you increase your testosterone, your liver has to clean it up. This was no problem before finasteride because we all had our 5AR2 to synthesize it to DHT. However, because finasteride stopped the testosterone to DHT conversion, then the liver had to increase a lot more aromatase to get rid of all the extra testosterone. An overload of testosterone in the body is like poision, it will cause issues. So all the extra testosterone got converted to estrogen because of all the aromatase that was released by the liver. Now our bodies are stuck in a bad loop because our 5AR2 gene got ruined, and everyone’s daily masturbation on this forum kept causing issues. Read like everyone’'s story on here, everyone crashes after masturbation. I read like random threads about people saying they can masturbate like 3x in a day during a “brief recovery” and then by some strange and unexplainable act they crash again.
I see other people posting that they crash after masturbation so I know it’s not just me. If what you are saying is true, then EVERYONE who took it would have crashed the way we did.
what i’m guessing what happened was that everyone had high stress + daily masturbation, which basically had their body on overload with adrenaline. now you factor in finasteride, now e2 is causing inflammation throughout the body. this is the only theory that makes sense to me that can effect every body system thats effected by people. when you burn out your dopamine, serotonin, and acetylcholine in your brain from masturbating (yes, these are released everytime you masturbate, look it up) they control A LOTTT of systems in the body (including digestion, muscular systems, mood)
and that’s a THEORY people… but it makes a lot of sense to me.
so everytime you masturbate, you increase your testosterone, and because your 5AR2 gene is damaged, there is too much testosterone in your body that is not being converted to DHT, so your liver is forced to release aromatase to convert all that extra testosterone because it can’t handle into into excess estrogen
low LH + Low free test + high estrogen would indicate estrogen overload probably.
For me this seems to be the case. Free test below range. E in range. so Free test : Estrogen ratio looks bad.
I am trying to figure out the mechanism that could explain increased aromataze?
Some people say could be liver not clearing the estrogen out.
A few people have got better on arimidex, including me. This seems to point the finger at too much estrogen, at least in my case.
My libido for the first couple weeks on finasteride did not drop much. But then after a couple weeks or so it went to nothing. I remember there was one point when I was on fin that I looked at some porn and I was more turned on than ever it was like hyperstimulation. I would like to try to explain why this was. Perhaps my testosterone was backing up and at that point my testosterone was higher than usual. As I was on finasteride DHT should have lowered.
I am not trying to work on eveyones problems here, just mine. And so far, eveything is pointing that in my case estrogen / free test is possibly the main problem causing all my symptoms.
Any one have any more ideas how aromatze could be upregulated? Could have the lack of DHT caused my balls to think they should really behave more like overies? Seems like a stretch.
The increase in libido during finasteride is due to the fact that testosterone is becoming estrogen and not DHT. Your brain detects estrogen and this is responsible in part for libido. My endocrinologist (who is senior professor at top university) explained this to me. He actually wants me to lower my clomid dose so that my brain detects more estrogen and he said this should result in higher libido.
As to why I am still having the numb penis, shrinkage, anhedonia and all that other shit, he doesn’t know why/can’t explain it. He’s dumbfounded.
I do not believe that is true in my case. I have pregnenolone and DHEA, when I take them they seem to convert to estrogen as I get muscle twitches, emotional and it really messes up my outlook. I also have a tub of estrogen cream here that I will experiment with, but I am 95% sure that it will cause similar problems to DHEA.
Muscle twitches are associated with estrogen HRT for women.
If you read the medical studies on pub med, you will see that both estrogen and testosterone is needed for healthy sexual function in many species.
If your estrogen in in range that should be enough. If it is low then that could be a problem.
Do you have your free test results and estrogen results? Please post them
