I have tried numerous things and it always seems like testosterone did nothing. I started researching and finding out that Estrogen is a major player in sex drive. I had try a low dose of estrogen valerate which seemed to help improve my mood but I also tried Estradiol Gel and it has made the most dramatic improvement in my overall health. I am trying to figure out what is happening exactly. I noticed that my facial hair is coming in thicker and it is even helping my hair fall out so somehow it is affecting DHT levels. The best part of all of this is that my sex drive is through the roof at times. If we stop looking at hormones as guys and girls we may be able to start understanding what things really do. Somehow the gel is affecting 5ar activity is the only thing I can think of because I am under the impression that dht is not down stream of estradiol.