I simply thought: if the cause of our problem is epigenetic as we say, we should reverse it with the same epigenetics, that is, with an “Epigenetic Therapy”. https://en.wikipedia.org/wiki/Epigenetic_therapy I hope a cure will come for us.
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thats why im trying in a few months a demethylating agent mentioned in ur article
i expect at least a partial recovery from this.
If the epigenetic theory than yes,with DNA hypomethylating drugs or HDCA Inhibitors the problem should be reversed
My friend figured that because 5-azaC goes into RNA and RNA affects all cell cycles,than the drug should touch all cells and help us
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Yes Exactly. Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs).
It could be the cure for our Syndrome of Finasteride.
Are you going to try this?
Onestly, I’m afraid. We need security studies.
https://www.invivogen.com/trichostatin-a
The cost is high, we do not know security.
It may be dangerous.
I’ll help you pay for it I’m intrigued
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It could be very dangerous. We do not know how we can react to the drug. I do not even know if it’s for human use or research. It could be toxic-deadly. I have to talk before to Melcangi about it.
I’ve actually been looking into HDAC Inhibitors for a while… I did mention it to the PFS Foundation at one point and they seemed kinda interested but not totally sold. If you really dig through search history here, there was one guy who said it reversed his symptoms and then another who said it made him worse. 50/50 didn’t seem like good odds to me… Wasn’t willing to take the risk.
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In fact, they are only for research apparently.
The guy what did he assume of specific?
I would personally discourage offering to pay for another member to conduct a trial of something. My concern would be if it had the potential to cause harm. It would be easier for someone else to take that risk, but I would be concerned that there could be an exploitation of desperate, vulnerable members who might just take that leap. I’m not saying that you are doing this of course, but I am only saying this out of a concern that in the future an offer might be made to a vulnerable member to take a problematic medication when they otherwise wouldn’t have without both this encouragement and offer of payment.
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luckely he doesnt know what he is talking about
the trichostatin A is not available comercially
and the other guy is scared to death of taking anything so i wouldnt worry 
Yeah honestly I wouldn’t fund if it was against the community opinion, thanks man
Not commercially available, but for research.
1mg 104,00€
5mg 380,00€
Here https://www.invivogen.com/trichostatin-a
"Our data show that HDAC inhibitors decrease AR protein levels by inhibiting transcription of AR without significantly affecting AR protein stability, as previously reported "
I myself say that it is not safe, it can be dangerous. I have to talk to Melcangi about it.
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