Endogenous neurosteroid synthesis modulates seizure frequency

Hi guys I just came across this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918659/
Some interesting parts:

Finasteride blocks the synthesis of neurosteroids such as allopregnanolone and THDOC in the brain in a dose-dependent fashion(14). Other studies demonstrated that finasteride causes serum neurosteroid levels to decline and progesterone levels to rise(15). The breakdown of existing neurosteroids and the decline in brain neurosteroid levels is likely to take some time after finasteride administration.

‘‘Finally replenishing allopregnanolone after finasteride administration terminated seizures quickly and lower dose of finasteride did not cause significant seizure exacerbation. Our attempt to measure serum neurosteroid levels was unsuccessful but finasteride administration increased serum progesterone levels consistent with the enzyme inhibition effect of finasteride. Seizure exacerbation as a result of finasteride administration has been reported in one patient with epilepsy’’