Emerging Roles for Neurosteroids in Sexual Behavior and Function

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#1

Highly recommend people have a read through the entire article linked below.

Emerging Roles for Neurosteroids in Sexual Behavior and Function
andrologyjournal.org/cgi/con … l/29/5/524

Abstract

Although gonadal and adrenal steroids heavily impact sexual function at the level of the brain, the nervous system also produces its own steroids de novo that may regulate sexual behavior and reproduction.

Current evidence points to important roles for neurosteroids in sexual and gender-typical behaviors, control of ovulation, and behaviors that strongly influence sexual interest and motivation like aggression, anxiety and depression.

At the cellular level, neurosteroids act through stimulating rapid changes in excitability and direct activation of membrane receptors in neurons.

Thus, unlike peripheral steroids, neurosteroids can have immediate and specific effects on select neuronal pathways to regulate sexual function.

#2

Seems my endo knows what he is saying, nevertheless he has no idea how to fix this. he said something that neurosteroids are highly underestimated by endocrynologists and sexuologists.

#3

Finasteride mentioned. Further supports that inhibited GABA and allopregnanolone are a big piece of the puzzle.

andrologyjournal.org/cgi/con … l/29/5/524

#4

Neurosteroids may also influence male sexual behavior through GABAA receptors. Allopregnanolone has been shown in male rats to potentiate GABAA channel activity in neurons in the medial POA, a region that also produces neurosteroids and is essential for sexual interest, erection, copulation, and ejaculation

Is it possible to test allopregnanolone? based on reading this article this could be easily as significant as DHT in post fin sexual dysfunction.

From Wikipedia:

The endogenous production of allopregnanolone starts with 5α-reductase converting progesterone into dihydroprogesterone. After that, 3α-hydroxysteroid oxidoreductase isoenzymes (also referred to as 3α-hydroxysteroid dehydrogenase) converts this intermediate into allopregnanolone.

So whilst taking finasteride our bodies were unable to convert progesterone (which inhibits sexual behaviour) into allopregnanolone (which is required for sexual behaviour)?

#5

Not commercially, no. Likely only in a research lab. But, call up a psychiatrist’s office, maybe they can special order the test?

propeciahelp.com/forum/viewt … =7264#7264