Effect of prolactin on DNA methylation in the liver and kidn

[bryce54]

Prolactin is an important growth modulatory hormone in fetal and adult tissues. It stimulates DNA synthesis and enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. In this study the effects of prolactin on 5-methyl cytosine content in liver and kidney of rats was studied using HPLC. Prolactin treatment caused hypomethylation of DNA in the liver and kidney of immature rats at 48 h after treatment and the effect remained even at 72 h. Prolactin also caused hypomethylation of DNA in the kidney and liver of adult rats at 48 h after treatment. These results indicate that prolactin probably regulates DNA methylation in the liver and kidney of immature and adult rats.

ncbi.nlm.nih.gov/pubmed/2366751

prolactin goes up with masturbation
prolactin goes up with a low thyroid function

[ogadwolverine]

@bryce54

Prolactin is an important growth modulatory hormone in fetal and adult tissues. It stimulates DNA synthesis and enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. In this study the effects of prolactin on 5-methyl cytosine content in liver and kidney of rats was studied using HPLC. Prolactin treatment caused hypomethylation of DNA in the liver and kidney of immature rats at 48 h after treatment and the effect remained even at 72 h. Prolactin also caused hypomethylation of DNA in the kidney and liver of adult rats at 48 h after treatment. These results indicate that prolactin probably regulates DNA methylation in the liver and kidney of immature and adult rats.

ncbi.nlm.nih.gov/pubmed/2366751

prolactin goes up with masturbation
prolactin goes up with a low thyroid function

Good finding. But this is to far away from our problem, isn´t it? Everything changes DNA somehow, I have the feeling nowadays.

[Finatruth]

you really think our DNA changed? lol

[ogadwolverine]

@Finatruth

you really think our DNA changed? lol

Well, fuck I don´t know. How should I? DNA is changeable? I have heard about underexpression - overexpression - epigenetic change. What I mentioned meant these things - if you really wanted to know in detail.

lol? I haven´t laughted since February 2012. Where is the fun?

[bryce54]

@ogadwolverine

@bryce54

Prolactin is an important growth modulatory hormone in fetal and adult tissues. It stimulates DNA synthesis and enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. In this study the effects of prolactin on 5-methyl cytosine content in liver and kidney of rats was studied using HPLC. Prolactin treatment caused hypomethylation of DNA in the liver and kidney of immature rats at 48 h after treatment and the effect remained even at 72 h. Prolactin also caused hypomethylation of DNA in the kidney and liver of adult rats at 48 h after treatment. These results indicate that prolactin probably regulates DNA methylation in the liver and kidney of immature and adult rats.

ncbi.nlm.nih.gov/pubmed/2366751

prolactin goes up with masturbation
prolactin goes up with a low thyroid function

Good finding. But this is to far away from our problem, isn´t it? Everything changes DNA somehow, I have the feeling nowadays.

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