Effect of Cialis on oxygen-starved (hypoxic) penile tissues


#1

Effect of Chronic Tadalafil Administration on Penile Hypoxia Induced by Cavernous Neurotomy in the Rat

blackwell-synergy.com/doi/ab … 06.00208.x

ABSTRACT

Background. Numerous men develop postprostatectomy erectile dysfunction (PPED), due to surgery-related nervous damage. PPED is often refractory to phosphodiesterase type 5 (PDE5) inhibitors therapy.

Aim. To verify whether chronic tadalafil (CT) [Cialis] preserves bilateral cavernous neurotomy (BCN)-induced penile damage and hypo-oxygenation.

Methods. In a rat model of BCN we evaluated in vitro and ex vivo effect of CT [Cialis] treatment (2 mg/kg, daily for 3 months).

Results. Bilateral cavernous neurotomy induced massive hypoxia and decreased muscle/fiber ratio, completely restored by CT [Cialis]. Hypersensitivity of hypoxic tissues to the relaxant effect of the endothelin type B receptor (ETB) agonist IRL-1620 was observed, along with ETB mRNA and protein overexpression.

CT [Cialis] restored sensitivity to IRL-1620, and normalized ETB expression. Hypoxic penis showed increased sensitivity to the relaxant effect of the nitric oxide donor sodium nitroprusside (SNP), while acute tadalafil (100 nM) did not amplify the SNP effect.

Accordingly, PDE5 mRNA and protein were reduced in BCN penile tissues. By restoring PDE5, CT decreased SNP-induced relaxation and rescued sensitivity to acute tadalafil. However, in hypoxic penis, CT normalizes neither acetylcholine hyporesponsiveness nor neuronal nitric oxide synthase-endothelial nitric oxide synthase expression.

Conclusion. Chronic tadalafil [Cialis] restores some of the investigated BCN-induced alterations, including PDE5 and tadalafil efficacy.


#2

Anyone recovered (or tried to) with 5mg/day Cialis therapy? at least for 2-3 months


#3

this could be the study that crysler was talking about months ago


#4

Ciao prop :slight_smile:
This kind of therapy (5mg/day of Cialis) has been prescribed to me by 2 different urologists, to be followed at least for two months. They surely were aware of this kind of effect. The long half life of Cialis poses a neat preferency on it among other PDE inhibitors. I think I will follow it, if hopefully Cialis stops giving me headaches. Also it is unfortunately to be considered that:

onlinelibrary.wiley.com/doi/10.1 … ated=false


#5

ciao tab :slight_smile:

yes pde5i r often prescribed but this study gives more hope for a real healing therapy rather than symptomatic one

unfortunately i’m also scared about neurological sides


#6

What neurological sides?
I use viagra all the time but i tried 20 mg cialis once and i felt realy better for 2 weeks.

Cialis is also approved for prostatitis treatment,


#7

I think the problems are related to headaches and flu like symptoms. In fact I felt very well sexually whilst taking cialis and I had rock nighttime erections and some daytime spontaneous erections (which was something unexpected since I completely lost them from a lot of time). Unfortunately my sleep wasn’t that well due to headaches and some slight flu like symptoms. I cannot be sure but this clearly doesn’t appear to me as a good think. But I think this is anyway a good theraphy to try if hormones are ok. Maybe side effects might subside after some time. Or maybe we can add something to sleep better :mrgreen:
I will have to talk to my actual endo-andro before taking the way of long term cialis.

ps there are some relatively new studies on chronic use of Cialis for rehabilitation. I will take some time to post them as soon as possible.


#8

I think people rushing in to take cialis need to consider its sides, headaches and congestion are well known but it also causes muscle spasms and lower back pain among others.

Coincidentally I tried it myself after a longish break and had very sore legs a couple of days after taking about 5mg. PFS causes me enough pain already without taking drugs which add to it. It did give me strong nocturnal and morning erections though.


#9

Still makes you cialys effect?


#10

luckf did u take cialis longer? if yes did u had some lasting benefits after discontinuation?


#11

bump this ^^


#12

extremely sore back and joints from cialis, although normally i dont’t have any problems with back or legs. I was almost crying from pain. really weird. Maybe some autoimmune response.


#13

I have been on 5mg a day for around 6 months, though i am quite lazy taking it and in reality probably only take it 5 out of 7 days.
I do feel much better than where I started.
no miraculous recovery and as ever there is good periods and bad periods but on the whole it has been helpful.
Of course if this was just natural recovery or help from the cialis I can’t say.
No side effects for me, had headaches at the beginning but that quickly faded, though I notice if I take it late at night before sleep I get warped dreams but nothing major.


#14

Did the pain completely go away after you stop using the cialis?? Please respond me quick, im gonna order it today. I need to know this. @slick1


#15

@Cooper
Yes, it completely went away in 1-2 days, after i stopped stopped using it. IT was really bad experience , but its very rare side effect, so you can give it a try.