Original Research Article
Effect of Acetyl- L -Carnitine on Serum Levels of Cortisol and Adrenocorticotropic Hormone and Its Clinical Effect in Patients with Senile Dementia of Alzheimer Type
Parnetti L. · Gaiti A. · Mecocci P. · Gottfries C.G. · Santucci C. · Reboldi G.P. · Senin U.
Dement Geriatr Cogn Disord 1990;1:165–168
Eleven patients with senile dementia of Alzheimer type were treated with acetyl- L -carnitine (ALC) intravenously for 10 days and then orally for 50 days. Serum levels of cortisol and adrenocorticotropic hormone were measured at baseline and after the intravenous treatment. Neuropsychological assessment was also carried out at the same times and at the end of the oral treatment. The results show a trend toward a decrease of the mean cortisol levels and a significant improvement of cognitive performances. These data could support the idea of the neuronotrophic action of ALC, indicating its usefulness for the treatment of dementia disorders.
© 1990 S. Karger AG, Basel