Have you heard of KISS?
Keep it simple stupid.
Its an engineering philosophy.
Im going to add to some of this, I was on my lunch break earlier.
Oral isotretinoin (13-cis-retinoic acid) therapy in severe acne …
https://pubmed.ncbi.nlm.nih.gov › …
(https://pubmed.ncbi.nlm.nih.gov/2943822/)
The results suggest that isotretinoin therapy interferes with the endogenous vitamin A metabolism in the skin. Publication types. Clinical Trial;
Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes
13-cis-retinoic acid, and all-trans-retinoic acid are vitamin A derivatives used in the treatment of cancer and severe acne. Patients taking these drugs often show side effects resembling the symptoms of hypovitaminosis A, namely, night blindness and decreased plasma retinol levels. A dietary vitamin A deficiency is not suspected in these patients; therefore, interference with normal vitamin A metabolism seems likely.
^So this could possibly be the case both internally and externally.
So what gene changes were we seeing again @borax?
Approximately half of the significantly changed genes affected by 13- cis RA contained consensus sequences for RAR or RXR receptors.
What are some of these genes involved in?
The preponderance of genes that were downregulated at 8 weeks are involved in the metabolism of steroids, cholesterol and fatty acids,
This was that study from yesterday, I thought this was actually pretty good seeing this again.
Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain
One month after the last treatment (i.e., withdrawal period), some of these effects persisted (i.e., the upregulation of the androgen receptor in the cerebral cortex, an increase of dihydroprogesterone in the cerebellum, a decrease of dihydrotestosterone in plasma).
You can see how this is already getting a little messy so im going to end it right here for now.
Plus I just got off work and want to grab a beer.
I’ll be done here real soon.