Dutasteride is worse than Finasteride!

Dutasteride can inhibit 100% of DHT! :open_mouth:

The half life of Dutasteride is 5 weeks! :open_mouth:

If Dutasteride gets approved as a hair loss drug, you can be sure it will work wonders for some people, as it would not only delay hair loss like Propecia, but put it off completely! Then again, it will be Propecia’s successor of impotence hell! With a much longer half life, and much lower reduction of BOTH forms of DHT, you can be assured, it will be worse! :open_mouth:

Not sure what the point of your post is? Nobody here cares about using such drugs, wether its Fin or Dut, anymore. This isn’t a hairloss site.

DUT has been on the market for awhile now. Some guys tolerate DUT well, others get bad side effects. Same as with Fin. And it doesn’t completely stop hairloss, despite blocking more DHT than Fin.

Besides reducing up to 90% of DHT, the major problem with DUT is its a dual inhibitor, inhibiting both 5AR Type 2 AND 5AR Type 1.

Unfortunately it is Type 1 which is found predominantly in the brain, and nobody knows what the long-term implications of such inhibition may be.

How much type 1 DHT is inhibited by finasteride? I’m under the impressino finasteride is a type II DHT selective inhibitor.

Dutasteride ruined my life. I started Dutasteride after Propecia and I am a complete zombie now. The drug made me completely psychotic while I was on it and completely emotionless now that I am off. I can’t even make friends anymore and I used to be a social butterfly, laid back, easy going, funny around friends with the whole world ahead of me.

The half life of finasteride’s effect on the enzyme 5AR (binding to it to create dihydrofinasteride) is about 30 days, more or less. This is different from the serum level of finasteride, which is about 4.5 hours and pretty much gone in 24 hours, hence the raison-etre for taking finasteride everyday. Dutasteride’s is probably a good deal longer (perhaps in the ballpark of a handful of months).

So four months after quitting finasteride (finasteride only), 1/16 of the 5AR enzymes are still bound, although it could be as high as 1/8 still.

I’ve read that dialysis unbinds finasteride from the enzyme 5AR. It may also work for dutasteride. For the record, I’m not sure what dialysis they’re talking about, whether it’s renal dialysis (sending blood through an external machine to cleanse it) or something else.

And what do you base this ā€œequationā€ and concept on?

I base it on the literature you posted under the finasteride studies section, noting that the half life of finasteride’s effect on the enzyme is about 30 days. Am I not right or what?

Right, so if its 30 days (1 month) from last Fin dose for ā€œunbindingā€ of 5AR2 to take place… then where do you come up with the concept that enzymes are still being bound after 4 months (120 days) at these fractional values?

If the half life is 30 days, that means after 30 days of quitting, half of the enzymes that were bound while on finasteride should be unbound. Then after 30 days after that, half of the remaining enzymes should be unbound, or 1/4 of the original bound enzymes, 1/8 for three months and 1/16 for four months (ah yes I did the math wrong).