Here is a snipet he doesn’t want the whole thing out yet he said they would be publishing it in May…Its 7 pages and of course there os no mention of what he actually gives you or what the analysis involves but I assume you would have to mail in a stool sample… I mailed several viles of blood in 2017 to Gordon…
I dont think it’s breaking any rules here just for educational purposes only
Finasteride disrupts the gut microbiome, it can trigger a cascade of neurological, immune, and metabolic
dysfunctions, owing to the intricate relationships between the gut-brain, gut-immune, and gut-endocrine
axes (Gordon et al., 2021). The gut microbiome plays a fundamental role in neurotransmitter production,
immune regulation, and hormonal balance, and its dysregulation may contribute to a wide array of
psychological and physical symptoms ( et al., 2022).
Psychological Complaints
Finasteride-induced gut dysbiosis may significantly impact mental health and cognitive function, as
alterations in short-chain fatty acids (SCFAs), neurotransmitter synthesis, and inflammatory signaling
directly influence brain function (Johnson et al., 2023). One of the most common neuropsychiatric
complaints associated with Finasteride use is anxiety and depression, which may be driven by disruptions
in serotonin and gamma-aminobutyric acid (GABA) production, both of which rely on Lactobacillus and
Bifidobacterium species for synthesis ( , 2023). A reduction in these beneficial microbes may lead to mood
instability, heightened stress responses, and increased susceptibility to depression.
Cognitive impairment, often described as “brain fog,” is another frequently reported issue, characterized by
poor concentration, memory deficits, and slowed cognitive processing ( et al., 2024). The decline in
butyrate-producing bacteria (Faecalibacterium prausnitzii and Roseburia spp.) may impair vagus nerve
signaling, reducing neuroprotective effects and increasing neuroinflammation, both of which are implicated
in cognitive dysfunction and neurodegeneration ( et al., 2023). Additionally, the systemic inflammation
caused by gut permeability (“leaky gut”) may lead to the excessive production of pro-inflammatory
cytokines such as TNF-α and IL-6, which can cross the blood-brain barrier, further exacerbating cognitive
decline and emotional dysregulation ( , 2024).
Sleep disturbances and insomnia are also common among Finasteride users, as gut dysbiosis can impair
melatonin synthesis, a hormone derived from serotonin, which is heavily influenced by gut microbiota
composition ( et al., 2021). Users experiencing post-Finasteride syndrome (PFS) often report irritability,
mood swings, and emotional hypersensitivity, symptoms that may stem from the dysregulation of gut-
derived neurotransmitters and chronic neuroinflammation (Smith et al., 2022)
Physical Complaints
Beyond neurological effects, Finasteride-induced gut dysbiosis can manifest in a range of systemic and
metabolic issues, as microbial imbalances play a critical role in immune function, energy metabolism, and
hormonal regulation ( et al., 2023). Gastrointestinal disturbances such as bloating, gas, diarrhea, and
constipation often arise from a depletion of SCFA-producing bacteria, leading to increased gut permeability
and altered digestion ( , 2023). Chronic low-grade systemic inflammation due to LPS translocation may
contribute to fatigue, joint pain, and muscle weakness, symptoms commonly reported by long-term
Finasteride users ( et al., 2024).
Additionally, the disruption of gut-derived testosterone metabolism may result in hormonal imbalances,
exacerbating low libido, erectile dysfunction, and metabolic disturbances ( et al., 2023). The shift toward
an estrogen-dominant microbiome profile due to androgen suppression may also contribute to gynecomastia
(male breast tissue growth), weight gain, and altered fat distribution ( , 2024).
Skin-related issues, such as acne, rosacea, and unexplained rashes, may stem from gut dysbiosis-driven
inflammation, as the gut-skin axis is heavily influenced by microbial diversity and SCFA production
(Gordon et al., 2021). Immune dysregulation may also increase susceptibility to infections, while promoting
autoimmune disorders such as thyroid dysfunction, inflammatory arthritis, and chronic inflammatory syndromes…
