Doxazosin...treatment at the genomic level?

Therapeutic Efforts Pharmaceutical
#30

last friday before starting doxazosin i injected 70mg of testosterone acetate to “challenge” the androgen receptors and had maybe 10-15% response the following days

yesterday i repeated the same dose at same time and woke up with raging boners today, i´d speculate a 60-70% response based on my experience

obviously too early to tell and i´d not discount placebo but this has not happened the last month while blasting trenbolone or testosterone

also got funny reactions i´d say from combining the HIV drugs with LDN like waking up with the strongest pins & needles i felt in life(it maybe the b6 on my ldn which is known to trigger PN)

also my neck/trapezius was tense the whole night, strange as fuck
the explanation i came with is that this is the region most abundant in AR and one of the drugs is sensitizing them again

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#31

still here

will not let you people in the dark
i can feel the valproate helping, the thing with it is that the “critical period” it opens up is a 2 way road

that weekend i got played by this girl i had lots of hope with… i think this is the worst i felt mentally in life, guess she noticed I’m not very well lately.

when the hardware is not upto the software can’t make for it right

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#32

How is your Prep experience ?

#33

im hoping it works

#34

Godspeed man, when did you start the prep?

#35

10 days ago, i can feel the sensitivity coming back its just that my mind is not at it feels so damn alien

in 6 days I’ll take a shot of triptorelin to reset my hpt-axis from 5 years of trt lets see how it goes

#36

So you attribute that to the doxazosin or the prep? And I’m glad you’re making improvements somewhere, thanks for sharing with us and not just leaving the forum forever

#37

just pinned triptorelin today loaded on nolvadex as recommended on pedsr.com

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#38

…In for updates. How’s this going?

#39

hi,

got the bloodwork yesterday, tripto worked for getting my HPTA back online in a couple weeks, this is the first time i used it and im pleased

the doxazosin doesn´t help long term i think(only pre-sex)
now im using forskollin which does the opposite of doxazosin(alpha-1 agonist)
this was recommended by the smartest doctor that i kknow so i gave it a shot

i finished my tenofovir bottle 2-3 weeks ago and didn´t get more
also stopped the valproate/hydralazine but now that im producing testosterone again i´ll give it another go

i should update here in 2-3 weeks max when i plan going back to TRT with the longest testosterone ester i found, i have a theory that AR hypersensitivity can respond to highly stable serum levels, i remember reading somewhere a report of someone with pfs that used test undecanoate with success so thats what im trying next

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#40

The doctor gave me doxacosin against high bload pressure. After 2 days i did not have any ejaculate by masturbating! I was surprised and we changed to another . After 2 days i had ejaculate again. I never will touch doxacosin again! It is poison!

#41

I have been using test undecanoate (Nebido) for 3 years as TRT and don’t really feel that the TRT has been doing anything. I may discontinue soon.

#42

What do your blood tests look like? Total test, free test, SHBG, estradiol, etc.?

#43

i only did lh

#44

before making conclusions you need to tell us the dose/frequency of injections, most doctors don´t prescribe it with AR hypersensitivity in mind

#45

It varies somewhat across the 3 months between injections, but even after around 2 month mark my T is toward high end of normal. My E is not high at all. The other two are unremarkable — normal basically. I once went off completely for 3 months (missed an injection) and felt no noticeable difference. Not trying to discourage you, we are all different, just letting you know it hasn’t been a success for one person. Other than that it hasn’t worked in solving the problem I went on it for, I like Nebido a lot. It’s been nice to at least know my T is always solid without having to bother about it at all except on 4 days a year.

#46

It’s only available in one dose and I only get it once every 3 months because my blood tests showed it’s still working well at 3 month mark.

#47

nebido’s half life is 20 days
“bodybuilding stable” levels are 3 injections per half life
so for nebido it means once a week maximum

i know this is how your doctor tell you to do but i also know a lot of people that tried other ways and reported high frequency is better

#48

Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth.

After all Finasteride was suppose to prevent prostate cancer.

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#49

My T levels are stable for 3 months. In this case I really think the doctors do know what they are doing. People in countries where Nebido is available generally seem to love it.