Down Regulation of AR

[inLimbo1]

mnn

[Mew]

Anytime you post quotes, CITE YOUR SOURCES, PLEASE. Provide link to the original article.

It would also be helpful if you wrapped the text you’re quoting in QUOTE tags (highlight text to quote, then click"Quote" button in the editor) so its easier to distinguish between YOUR thoughts, and the quoted text.

Finally, since you’re interested in AR downregulation/insensitivity side of things, have a read through the sticky post at top of this subforum if you haven’t already… since what you’re bringing up has already been discussed:

“Finasteride caused Androgen Insensitivity or altered Gene Expression?”
propeciahelp.com/forum/viewtopic.php?t=2216

[inLimbo1]

The Role of Androgen Receptors in the Masculinization of Brain and Behavior: What we’ve learned from the Testicular Feminization Mutation

ncbi.nlm.nih.gov:80/pmc/articles/PMC2706155/

[Oscar]

Thought I would post this before i forget about it. Good article on Accutane and AR’s
… …what is this cystolic protein?..

Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients

An oral daily dose (mean +/- SD, 0.75 +/- 0.05 mg/kg) of isotretinoin was administered for 3 months to six male patients with acne (scores of 4 and 5 according to Rosenfield). The therapy resulted in complete resolution of acne in four patients and improved acne significantly (score 1) in two patients. In accordance with recent findings, no change in serum testosterone and [b][Size=4]significant decreases in 5 alpha- dihydrotestosterone, 5 alpha-androstane-3 alpha,17 beta-diol glucosiduronate, and androsterone glucosiduronate levels were observed after treatment.

Androgen receptor status was investigated in back skin biopsies[/size][/b] obtained in acne areas before and after 3 months of isotretinoin treatment. [Size=4]The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein)[/size], as assessed by Scatchard plot and confirmed immunologically by Western blot analysis. [Size=4]These data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients[/size].

[Size=4]The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment [/size]appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne. Indeed, sebum production is under androgen control, and an abnormal response of the pilosebaceous unit to androgens appears to be implicated in the pathogenesis of acne. [Size=4]These observations were consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites[/size]

jcem.endojournals.org/cgi/content/abstract/80/4/115