I’m feeling really well on Metformin. It chilled me and brought mental clarity. And brought down the inflammation.
It is being a really nice complement.
The thing is that comes from some pros and contra.
It decreasses/downregulate AR expression.
Is an HDAC inhibitor, thus causing demethylation.
Is anti inflammatory by itself.
But also lowers testosterone from -15/-40% in various studies.
Honestly, i don’t know to which point this is good or bad, some people get bad increasing androgens and other have relief doing the opposite.
If you were me, would you stay on it seeing the mental improvements, or you would quit cause “reduces testosterone” ?