Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial

Interesting soon to be study right here.

A potential link exists between prostate cancer (PCa) disease and treatment and increased inflammatory levels from gut dysbiosis.

Androgen deprivation therapy (ADT) is extensively used as a neoadjuvant, adjuvant and/or standalone treatment for men with prostate cancer (PCa);6 however, survivors are burdened with persistent adverse effects of ADT including GI complications.7–11Despite a paucity of research into the mechanisms associated with GI diseases in PCa survivors, it is hypothesised that a dysbiotic composition of the gut microbiome may mediate negative outcomes of GI complications associated with PCa.12–15 Indeed, results from murine models demonstrate that castration and antiandrogens can affect the composition of gut microbiota.16 17 The complex, dynamic interaction between sex hormones and gut microbiome is still poorly understood.18