I’m having an extremely hard time trying to find information about what specifically causes your penis to have sensitivity. Some substance in our body is causing people’s penises to go numb or not to go numb.
The best two guesses I have at this point that would cause penis sensitivity issues are nitric oxide and a bad ratio of E1/E3 to E2.
Are there any other specific substances besides those mentioned above that play a part in penis health/sensitivity? Or do you know if one of those for sure play a part? Or is there not enough research done to know it? I know if you look deep in the internet, some answers are there, although not common.
Right, I agree with you that it’s the nerves in the penile foreskin that are being affected. However, there has to be something in our body that is affecting those specific nerves. The penis nerves can’t be necessarily generic nerves that are the same as everything else in the body. If that was the case, then people would be dealing with random sensitivity issues throughout the entire body, right? There’s some specific substances or hormones or whatever that specifically deal with only penis sensitivity. Like some specific precursor to the nerves in the penis. Perhaps, its just not known or researched well enough or will take some serious effort to find…
Genital tissue is full of 5AR2 and androgen receptors, amongst other things. Finasteride inhibits 5AR2/DHT (androgen), Nitric Oxide and various other elements in those tissues.
Do some basic research on the molecular aspects of penile/genital tissue and the influence of androgens on such. Nerves that are maintained by those precursors, would therefore likely be affected in a detrimental way (ie, apoptosis = cell death)… possibly causing the penile/scrotal numbness many complain about on the drug and since quitting, which did not reverse (as in my case).
Yeah, that’s why I was thinking nitric oxide since its primarily responsible for filling your penis with blood and then pooling blood out.
I don’t think it’s 5AR2 or DHT directly that would cause it. Lots of people have normal hormone levels, including DHT, which I think outrules it. Mew, I think when you said “various other elements”, right one of those other elements causes it. Right now, I’m leaning towards NO.
Anyone else have any input on this or have information on this?
And I agree with you Tim, the problem is not necessarily in the penis specifically. I think the reaction is going on somewhere, than those reactions are hitting the penis in a negative way.
I agree that the nerves in the penis have not died. I had insensitivity in my penis for the entire time I was on finasteride, but within a week of quitting, my penis felt great again. Then came the crash, and the numbness returned. This leads me to believe that the nerves are not dead, but something is preventing them from working. There are also times where ejaculating feels much better than other times, etc.
My experience is that the nerves are not dead, no way. If i fix the root cause then everything is fine. When i have experienced recoveries i have gone back to the very high sex drive i used to have i.e. sex anytime, upwards 5 times in a day very easily.
I don’t know about anyone else that has experienced temporary recoveries but the most pronounced sensation was around the prostate area. I can remember in August, i was unbelievably horny. I had an amazing feeling running through my prostate and groin area and would become erect even at the sight of cleavage.
I have no idea how i could go from that to the abysmal state i am usually in. It is beyond me. I seriously think that we might have just completely fucked up our prostates. I never even knew what a prostate was when i was taking finasteride - if i did i probably would of never touched it because i now know how important it is to male health.
"Traish thinks that may be because nerves that are maintained by dihydrotestosterone become permanently degraded and can’t be repaired even after men come off the medication."
FYI Dr. Traish is a PHD Molecular Biologist who wrote the paper “Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients” – onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2010.02157.x/abstract
according to traish ther’s no cure
but why some have days when sensitivity is back?
could be an inflamation? (at least for some)
However why i don’t see people taking nerve tests instead of hormonal?
imao
Sensory evoked potentials SEP
Somatosensory Evoked Potentials SSEPs
Somatosensory Evoked Potentials pudendal nerve(SEPPNs)
sensory conduction velocity of the dorsal nerve of the penis (SCVDNP)
pudendal nerve terminal motor latencies (PNTMLs)
bulbocavernosus reflex latencies BCRLs
prop,
thanks for listing all the nerves. Very interesting. Have you tested all those nerves.
I have done two tests with two different doctors and all turnde out fine. However, I don’t know if they have tested all those nerves.
One question to Dr. Traish:
“Traish thinks that may be because nerves that are maintained by dihydrotestosterone become permanently degraded and can’t be repaired even after men come off the medication.”
Does anyone know if we can test for nerve damage induced by a lack of DHT? I guess not.
Do you know what effects those nerves specifically prop? Like what is the precursor to those nerves. I’m just trying to find out what exactly is the cause of the numbness, and than work your way up the line fixing each step.
right, i agree theres multiple factors much more complicated than simply hormones, however, because the penis numbness and flucation is affecting mostly the penis itself, it tells me that the hormones play a large part. like how Mew is talking about DHT being lost, DHT/test have a large part in making nitric oxide, than it moves down the line, etc.
somethign is obviously not being synthesized correctly or being used correctly or something. i;m wondering maybe if it makes more sense to look into how the hormones or synthesized or how they are actually used, but based on people’s DHT/test levels… it seems to be normal… so I’m wondering if we work down the line from DHT/test and up the line from specific whatever it is that actually causes penile numbness, we’ll find the issue where stuff isn’t firing right… i just need to know what to look for… at this point, my best guess is still nitric oxide because numbness starts inside the penis, than works it way out to skin.
i don’t know bryce, but i guess by forum experiences that standard hormonal tests are useless.
imao only hi research test could show the root cause (they r working at), but we have to deal with damaged parts so best for us is target exactly parts involved
this is possible only with objective data from specific area tests
so, if the numbness is a widespread symptom, is necessary to spend more time on nerve tests then tring to cure that parts (if possible)
