Hello all 
Have any of you had any experience with agomelatine against anhedonia / numbed emotions? Although I am almost 100% impotent, it is the massive anhedonia / numbed emotions that plagues me most about this disorder (PSSD). I would even consider giving up all my sexual functionality if I could take emotions for it again.
Unfortunately I am not able to understand the medical aspects of our disorder well. However, I am very well able to observe my symptoms. In the early days of my disorder there were moments when I suddenly felt better for some time. In these moments I noticed very seriously that my prefrontal cortex was active again. I realized more emotions again and my sexual functionality usually increased at the same time.
I could imagine that in PSSD something changes in the functionality of the serotonin receptors, which as a result leads to a lower release of dopamine. At least in my case I have the impression that exactly this effect is also responsible for the sexual impairments. Probably it is different with PFS / PAS.
Regarding agomelatine I found the following section on Wikipedia and in the official drug directory of my country:
“By antagonizing 5-HT2C, it disinhibits/increases noradrenaline and dopamine release specifically in the frontal cortex. Therefore, it is sometimes classified as a norepinephrine-dopamine disinhibitor. It has no influence on the extracellular levels of serotonin.”
So I came up with the idea that this drug might be worth a try. However, I haven’t read many testimonials from people with PSSD / PFS / PAS, possibly because the drug is not available in the United States.
I would be happy to read from you if you have any experience with Agomelatine or if you can provide more information about my considerations.
Best regards,
trego94