Does any body knows accutane + 5 ARs--------->?

[spstriken]

I want to know how accutane looks like after binding 5 ARs with it. Does it become something like DHfinasteride or some thing else. DHfinasteride and DHtestosterone look very similar.

Also does accutane binds 5ARs permanently like finasteride does?
any body, biologist ,Scientist etc. I need to know this.

[Dubya_B]

any body, biologist ,Scientist etc. I need to know this.

You said any body. I’ll try to answer the best I can.

Also does accutane binds 5ARs permanently like finasteride does?

I’m pretty sure accutane (isotretinoin) doesn’t bind and deactivate 5AR1 the way finasteride does 5AR2. It appears to inhibit 5AR through a different mechanism:

(isotretinoin/accutane is a form of retinoic acid)

The effect of retinoic acid (RA) on testosterone metabolism was examined in a prostatic cancer cell line of human origin, PC-3. In cells growing as monolayers as well as in cell homogenates RA causes a dose-dependent inhibition of the 5 alpha-reductase activity, thus preventing the conversion of testosterone into its hormonally active metabolite, dihydrotestosterone. Fifty per cent inhibition of the enzyme activity occurred at an RA concentration of 2 x 10(-5)M. The pattern of inhibition was that of a non-competitive inhibitor. However, when incubations were performed in the presence of varying amounts of NADPH, it turned out that RA exerts its effect by competitive inhibition of the cofactor action

The conversion of testosterone to DHT by 5 alpha-reductase was reduced in the presence of retinoic acid. The inhibition was probably due to competition with NADPH for enzyme binding sites. The degree of inhibition found with retinoic acid at a concentration of 10(-4)M was greater for hyperplastic (41%) than that for neoplastic tissue (24%). The inhibition of 5 alpha-reductase by retinoic acid was dose-dependent.

http://www.ncbi.nlm.nih.gov/pubmed/3695521
http://www.ncbi.nlm.nih.gov/pubmed/1695368

[bryce54]

this might be of interest to u… not sure of the truth behind it tho…

immortalhair.forumandco.com/t754-sebum-and-dht-and-accutane

I read this over at hairlosstalk.com and thought it interesting. Wanted to share with you guys.

Ok I was at my GP not too long ago, an Egyptian doctor who I have been seeing for about a decade.

For the first time we spoke about my hair loss, well well fkn well… what a surprise when that topic was brought up.

Turns out he used to work for Merck & Sharpe as a researcher back in Egypt and he was booted out for his theory on hair loss. This is no bullshit… this guy was a fkn knowledge machine. All this time!

DHT isn’t the cause of hair loss is. Sebum is. This is why:

DHT triggers the glands in your follicle to overproduce sebum. Bacteria gathers in this overflow and your immune system then attacks the bacteria, INCLUDING the hair follicle with inflammation. He said it’s very similar to the process of acne.

Propecia works by stopping the DHT triggering the sebum overflow. He said Propecia could make your hair worse if like me hyperandrogenicity causes the extra oil.

He said he proved this theory by putting an early stage patient on low dose accutane. He said the patient regrew hair. He said this is why Retinoid helps, not because it tackles DHT, but because it tackles the sebaceous gland and stops the production of sebum… hence stopping the gathering of bacteria… hence no inflammation and no immune response.

I also asked why some medications work and why some don’t. He said in theory it should work for all, but there are 2 reasons it doesnt:

1. Internal drugs can cause hyperandrogenicity like I’ve experienced
2. Topical drugs don’t reach the follicle BECAUSE of the sebum build up blocking it. He said minoxidil works best with retin-A not because retin-A helps hair loss through DHT, but helps the minoxidil flow down the follicle wall by eliminating sebum build up.

He said he never really gave it the years of research it deserves, but his theory is ultra-low-doses of Accutane stops hair loss. He said 10mg twice a week will do the job.

He said when he kept trying to push this idea through his experiments, Merck kicked him off the research team."

[spstriken]

thanks bryce and Dubia.
I still want to know the structure of Acutane+5AR----->?

[spstriken]

just any one?

[spstriken]

Hi Guys

I need to know what the accutane looks like after binding 5 ARs.?
I know about finasteride and saw palmetto but not about Accutane.
since finasteride and saw palmetto (betasitosterol) look a lot like testosterone , they bind easily 5 ARs with them but Accutane has different structure so how it binds to 5 ARs.

[Mew]

Use Google Scholar and Google Books to find the answer to your own questions.

This isn’t an Accutane forum, btw.

[spstriken]

@Mew

Use Google Scholar and Google Books to find the answer to your own questions.

This isn’t an Accutane forum, btw.

I tried but could not find any so far.I think every body knows it is not an Accutane forum but it will help us how accutane works as a 5 AR inhibitor.

[visionquest99]

@Mew

This isn’t an Accutane forum, btw.

Someone purporting to be a mod from a site like PH likened accutane side fx with fin side fx. Given how proprietary we are about pfs, i take it this person is a mod at another fin site (?).

[spstriken]

@visionquest99

@Mew

This isn’t an Accutane forum, btw.

Someone purporting to be a mod from a site like PH likened accutane side fx with fin side fx. Given how proprietary we are about pfs, i take it this person is a mod at another fin site (?).

yeah. he seems to be Mew.

[Mew]

It’s not me and that msg is 2 years old.