Doctor Treatments

[mariobros]

From reading through the posts of people who have been treated by doctors like Crisler it seems as though most doctors are still treating post fin syndrome as a simple hormone imbalance and seem to be pushing TRT and other meds to correct testosterone levels.

The thing that seems strange to me is that from what i can see not one single doctor has looked at addressing a problem with 5ar2, which is where i believe all our problems stem from. (Reason: consistently low 3-Adiol G amongst sufferers and the fact that inhibiting 5ar2 is the primary function of propecia).

I’m curious if anyone has brought this point up with their doctor? There is research on this forums that identifies a few substances that have been shown to increase 5ar2 activity (morphine, minocycline, cyclo, gemfibrozil) none of these sound like the sort of thing you would want to take for the rest of your life, but if increasing 5ar2 could bring us back to homeostasis, wouldn’t it be worth a try?

I guess most doctors don’t really understand the intricacies of how finasteride effects the body or aren’t willing to try treatment without some sort of proof that it will work, so they just treat the symptoms they see with the treatments that their university textbooks dictate. next patient please!

i guess the disappointing thing is that even doctors like Crisler, who is spoken about on this forum like our messiah, doesn’t seem to have anything new or lets be honest, isn’t as motivated as people make out in regards to this condition. if he was as committed as people say why couldn’t he read through some of the theories and research on this forum?
if he believes he has an idea that could be causing this then he might find the missing piece somewhere here, make no mistake, guys like Mew know more about the effects of finasteride, 5ar2 and dht than most doctors.

I know that for some TRT has worked but it shouldn’t be the lifelong sentence for a kid who was just too naive to know what a supposedly safe drug was doing to his body and then have to pay for it for the rest of his life. i don’t know about anyone else but when my doctor first prescribed me propecia he made no mention about the effect that messing with hormones could have on your body or the importance of dht. to be honest i don’t think he had a fucking clue. this makes me wonder how much help can doctors really be? they don’t seem to know anything more about the effects of drugs than what they are given by the company that sells them.

But anyway, the point of this rant originally was to ask, has anyone brought up treatment aimed at addressing a problem with 5ar2 with their doctor or endocrinologist? and if so, what did they say?

[joetz]

I think you’re right. Until doctors figure out a way to treat the root of the problem intead of treating symptoms, we aren’t going to recover.

[JN1]

From reading through the posts of people who have been treated by doctors like Crisler it seems as though most doctors are still treating post fin syndrome as a simple hormone imbalance and seem to be pushing TRT and other meds to correct testosterone levels.

Yes, doctors won’t go out on a limb to correct us. My opinion is we will only get better by educating ourselves, taking some risks and sorting ourselves out.

The thing that seems strange to me is that from what i can see not one single doctor has looked at addressing a problem with 5ar2, which is where i believe all our problems stem from. (Reason: consistently low 3-Adiol G amongst sufferers and the fact that inhibiting 5ar2 is the primary function of propecia)

There is no way of easily upgrading the Type 2 enzyme intracellularly apart from the drugs you have mentioned (morphine, minocycline, cyclosporin) and I’m not touching those.

Homeostasis is defined as the ‘maintenance of a constant interior milieu’. I’m still looking for this milieu, and I’ve accepted it’s going to be a drug assisted milieu for life. In fact, the thought excites me. I’ve been at this for 9 years now, time is ticking by and I want my life back in its entirety, and with extra.

I guess most doctors don’t really understand the intricacies of how finasteride effects the body or aren’t willing to try treatment without some sort of proof that it will work, so they just treat the symptoms they see with the treatments that their university textbooks dictate. next patient please!

Exactly. Why should doctors care about this? There’s no money to be made, and it’s outside their comfort zone.

i guess the disappointing thing is that even doctors like Crisler, who is spoken about on this forum like our messiah, doesn’t seem to have anything new or lets be honest, isn’t as motivated as people make out in regards to this condition. if he was as committed as people say why couldn’t he read through some of the theories and research on this forum?
if he believes he has an idea that could be causing this then he might find the missing piece somewhere here, make no mistake, guys like Mew know more about the effects of finasteride, 5ar2 and dht than most doctors.

Exactly. That’s why we have to rely on ourselves. Only we can supply the time, energy and effort into getting better. One doesn’t need a MBCHB or an MD after their name to understand concepts and direct their treatment accordingly. Educating ourselves is vital as it will give us the power to make decisions regarding our treatment. Having spoken to Mew, he’s still hopeful of getting himself better without requiring lifelong drugs. Whilst this is admirable, I think it is an unrealistic aim. At some stage though, I’m sure his methodical ‘leave no stone unturned’ approach will uproot the cause of our problems. And maybe that’s what this is all about; time and patience.

I know that for some TRT has worked but it shouldn’t be the lifelong sentence for a kid who was just too naive to know what a supposedly safe drug was doing to his body and then have to pay for it for the rest of his life. i don’t know about anyone else but when my doctor first prescribed me propecia he made no mention about the effect that messing with hormones could have on your body or the importance of dht.

Tough shit, I suppose.

to be honest i don’t think he had a fucking clue. this makes me wonder how much help can doctors really be? they don’t seem to know anything more about the effects of drugs than what they are given by the company that sells them.

My endo doesn’t have a fucking clue. Now, when I meet him, he sits there and I educate him. He will do as I say because I know best. That’s why I think a printable booklet will be a good idea. I keep talking about this but have not got around to writing one yet. I think I may wait to see how Adiol G situation turns out (and with me, my response to DHT injections).

But anyway, the point of this rant originally was to ask, has anyone brought up treatment aimed at addressing a problem with 5ar2 with their doctor or endocrinologist? and if so, what did they say?

I’m already on TRT for life, and the addition of DHT injections should hopefully only enhance my life. I have researched means of upgrading 5AR2, but there are no specific agents available currently. It’s a question of papering over the cracks.

[ANewHope]

Old post, I know. But does anyone have an links to studies where anything has increased 5ar2 levels? It gets brought up a lot, but people seem to glance over it. Since there are alternate pathways for DHT creation (i.e. through 5ar1), low levels of 5ar2 could explain high levels of progesterone, since it is not being converted into allopregnanolone, all while retaining regular DHT levels. It would also explain why DHT therapy rarely works, since it’s not the lack of DHT but rather the lack of 5ar2 in order to convert progesterone into neurosteriods. This lack of conversion to neurosteriods also explains elevated E2 levels. It also explains why 3α-diol G frequently measures low in PFS sufferers. There is no other pathway other than 5ar2 to produce 3a-diol G. Regardless of believing this, does anyone have a study where 5ar2 was boosted using any treatments?