For those interested on Crispr and it’s potential to make changes to methylation.
“In the future, using these tools to establish direct links between transcriptional regulation and DNA methylation status will enable us to decipher the precise role of epigenetic modification in health and disease and will increase our overall understanding of the human genome.“
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When a CpG island in the promoter region of a gene is methylated , expression of the gene is repressed (it is turned off ). The addition of methyl groups is controlled at several different levels in cells and is carried out by a family of enzymes called DNA methyltransferases (DNMTs).
From Melcangis study
Results: SRD5A1 and SRD5A2 methylation analysis was performed in all blood samples (n = 16 PFS patients and n = 20 controls), in 16 CSF samples from PFS patients and in
13 CSF samples from controls. The SRD5A2 promoter was more frequently methylated
in CSF of PFS patients compared to controls (56.3 vs 7.7%). No promoter methylation
was detected in blood samples in both groups. No methylation occurred in the SRD5A1 promoter of both groups. Unmethylated controls compared to unmethylated SRD5A2 patients showed higher pregnenolone, dihydrotestosterone and dihydroprogesterone, together with lower testosterone CSF levels. Andrological and neurological assessments did not differ between methylated and unmethylated subjects.