Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut–testis axis

Effects of gut microbiota dysbiosis reach far beyond the gut. We aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired spermatogenesis.


January 2021

  • These findings represent the beginning for linking the testicular function and regulation of gut microbiota via host metabolomes.
  • Vitamin A metabolism might be applied to be a potential indicator for male infertility in individuals with MetS.
  • The regulation of vitamin A metabolism through restoring the gut microbial ecosystem will be of value for male infertility therapy in individuals with MetS.
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