Dihydrotestosterone stimulates 5 alpha-reductase activity in pubic skin

Damon · 2018-11-20 23:40:38 UTC

ncbi.nlm.nih.gov

Dihydrotestosterone stimulates 5 alpha-reductase activity in pubic skin fibroblasts.

I Mowszowicz, E Melanitou, MO Kirchhoffer and P Mauvais-Jarvis, The Journal of clinical endocrinology and metabolism, Feb 1983

In vivo, the 5 alpha-reduction of testosterone (T) to dihydrotestosterone (DHT) is androgen dependent in pubic skin but not in the skin of the external genitalia. The aim of the present study was to determine whether pubic skin fibroblasts (PSF) had retained this androgen dependency. PSF were prepared from explants of skin from normal subjects (four men, three women) and three patients with complete form of the testicular feminization syndrome. Culture medium containing 5% fetal calf serum and DHT was added 24 h after subculture (day 1) and renewed every other day. 5 alpha-Reductase was assayed on day 4 or day 8 by incubation of intact cell monolayers with [3H]T (2 nM), extraction of the medium, and chromatography of the metabolites; DNA was assayed in the cell pellets; 5 alpha-reductase was expressed as fmol/micrograms DNA . h. Controls were untreated plates from the same subcultures. DHT had no effect on cell DNA, whereas it resulted in a dose-dependent increase in 5 alpha-reductase activity. In seven PSF strains tested, DHT (10(-7) M) increased 5 alpha-reductase activity 2- to 4-fold over the control levels. This effect was abolished by the simultaneous addition of cyproterone acetate (2 X 10(-6) M) and was not observed in PSF from testicular feminization syndrome patients, suggesting that it was indeed mediated via the androgen receptor. T but not estradiol or cortisol also increased 5 alpha-reductase activity in PSF. The effect of androgens was suppressed by protein synthesis inhibitors. These data provide strong evidence that PSF respond to androgens via a receptor mediated mechanism, and that 5 alpha-reductase can be used as a marker of androgen action in pubic skin in vitro as well as in vivo.

But then We Should all do a massive dose of DHT to reverse the 5 alpha reductase and return to having sensitivity to the penis and rest of the body?

Rmoney96 · 2018-11-21 13:14:05 UTC

What makes you think this ?

Rmoney96 · 2018-11-22 10:40:31 UTC

Genuine question no disrespect whatsoever, I find it interesting as well

Scott.H · 2018-11-22 10:40:41 UTC

Curious as well. Aside from tribulus and other major t boosters. How would one take a huuuge dose of dht? Could this shock the system into coming back online?

Lostinaustin · 2018-12-31 19:43:21 UTC

I believe I’ve read of other users using topical dht cream (andractim I think it’s called?) on the genitals with good results but I don’t think they concluded that it was a cure.

Lostinaustin · 2019-01-02 15:44:51 UTC

Isn’t the theory that our problem stems from the big rush of DHT coming back after quitting propecia? It seems like this would just recreate that scenario

Cooper · 2019-01-02 15:44:42 UTC

If so, people must felt intense healthy sexuality just before the crash. And i never saw a case like that. Im not a PFS sufferer myself. So im not sure of course.

Invictus · 2019-01-03 14:22:09 UTC

Many felt even hypersexual before the crash, myself included.

Damon · 2019-01-03 14:22:47 UTC

Friend, I have not understood yet: with what did you have PFS with Soy?

Invictus · 2019-01-03 16:10:17 UTC

First I got only mild PFS from soy + calorie deficit. 2 years later I crashed harder from licorice extract and milk thistle.