Good words @borax and we now ‘more or less’ know where we need to focus on in terms of research and treatment . I’m sure like many id pump a lump into pushing this forward at greater pace. I expect there are one or two who have access to decent funds. Our lives and health are worth more than money. So hopefully those who can afford it will contribute generously
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Anyone have an idea what the control group is?
Just 26 men with normal sexuall health without pfs.
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It would have been interesting if they had another control group with people who use finasteride but doesn’t have any symtoms.
Anyone know if they will release the data on the over/underexpressed genes?
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Is there any mention of the neuropsychiatric and change in neurosteroids levels being associated with Finasteride and talk of the two suicides during the study? or is this study just primarily focused on sexual dysfunction?
Idk, if the AR gene is truly upregulated, I’m not sure if labeling PFS as a type of androgen deprivation syndrome would be the most accurate. It would seem androgen signaling is increased, not lost.
If you notice the screen shot I posted up in the first of the thread here the complete outline of the study there it appears it is all discussed…
I thought there was more to the study so that’s a no. Ok, thanks
How do you get full access to it?
This article is still listed as “in-press” and therefore most institutions libraries won’t have access yet. Once it is officially published, I will post it on here. That usually only takes a couple of weeks.
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No matter what this study has uncovered, I am extremely gratetful to the foundation and the people who devoted their time and resources to make it possible.
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Thanks to the Post-Finasteride Foundation
Funding: This study was funded by an unrestricted grant from the Post-Finasteride Foundation.
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It’s great news to see pfs being confirmed. I’m looking forward to the article being published so we can see the whole article.
Hope for god that only a few altered key genes cause the whole downstream casscade. 99% stopp Finistarid without any effect. 1% Show permanent alteration after Androgen increase.
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Yes, creating a sockpuppet account to fake a suicide note after the release of such a landmark study is quite bewildering. Also the same member had been active in our community for months and had a clear agenda to present the findings of this study as a death knell for all patients.
It doesn’t sound like good news.
I’ll wait for someone more knowledgeable to chime and possibly explain it to us, but from what I understand we can probably say goodbye to the perspective of a one-fits-all “therapy”.
It’s always like this.
Harsh as it may sound, trial and errors is the heart of progress.
Gene therapy targeting … all of 3000+ Expression altered genes?
I don’t know how the others feel about this, but to me this study is unequivocally bad news.
Pretty pathetic.
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Excited that this is finally out and excited for the Foundation’s statement on it.
Even if it won’t directly affect me in the next few years, hopefully it can lead to treatment options for our sons, nephews, and future PFSers of the world. No one should go through what we have.
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I’ve read the full paper and I still don’t understand some of it, but the study is really meaningful
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In best case there are only some key genes altered wich induce all the downstream effects. 99% get off Finistarid without any persisting downregulation or upregulation of these 3800 genes. So for me it seems to be induced by some hypersensitiv regulated genes in the genom of a very sensitiv community of men.
So does anyone know if this now proves are condition is real?? Can someone chime in.