Some members reported positive effects from a calcium/magnesium butyrate supplement.
But I think you have it backwards when you say it is like using a chainsaw to make sashimi. Butyrate supplements have a number of health benefits, at least in non-PFS people. Short chain fatty acids including butyrate are made by gut bacteria naturally. It can change the epigenome because it is a histone deacetylase inhibitor.
De-methylation drugs on the other hand are basically chemotherapy, often used to treat cancer. They come with all kinds of nasty side effects like, for example, wrecking the immune system.