I believe that some of you remember this post, where talk about bicalutamide, well bicalutamide is another HDAC inhibitor, but I prefer β - hydroxybutyrate over bicalutamide in term of safety.
Androgen receptor (AR) overexpression and sensitivity to hormones reversed by epigenetic therapy that restores Purα to a transcriptional repressor complex (RC) of AR deregulated in hormone refractory prostate cancer (HRPC) | Journal of Clinical Oncology
Bicalutamide is literally an antiandrogen.
It is but it doesn’t mean that will kill your androgen forever, as soon it can repair what is damaged the rest doesn’t matter because the androgen restore by then self,
a lot stuff are anti androgen even bananas, soybean, avocado, tomatoes and the list goes on…
All of these conditions (PSSD, PFS, PAS) are literally caused by temporary androgen ablation.
Yes but different molecules, different mechanism, in all those cases seem that occurred methyliation, now it seem that HDAC like Bicalutamide despite of being anti androgen fix what is broke.
Look fasting is anti androgenic, because fasting low LH, then low Testosterone and so on…but at the long run when you break the fasting seem that testosterone peak and you get an increase of T
Just take another HDACi such as beta hydroxybutyrate. An antiandrogen is literally the last thing I would take regardless of whether it has other properties which could help. And also you can’t really compare fasting with antiandrogenic substances. What happens during fasting is caused by mechanisms which have been developed by evolution after millions of years, so there will be no acute androgen ablation that antiandrogenic substances can cause.
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Did you ever read anything about beta hydroxybutyrate ?
What more amazing me is that you dare to take Propecia, and you are afraid to take B-hydroxybutyrate, if you think that you will reverse PFS with a drug without side effects or risk or naturally, do you know what? don’t read anymore about PFS and pretend that you never have it.
It is easy to be critical without even take the time of do any research.
Yes, I’ve ordered it as a supplement.
Are you saying the genetic stuff hasnt even started yet? Who gave you this information?
Did you mean to reply to someone else?
They only had collected the data, by the time that I meet Khera a couple months ago he told me that they were about to start comparing the data to start the second part of the study and the first part of the study was waiting for the approval for publication.
I am sorry guys I will like to have better news.
As I said before, I am 48, my grandsons will be seating in my grave waiting for the result of the study.
If you compare others disease research vs PFS in scale of interest 1- to 10
I will say that PFS is no reaching 1.
PFS is 0.01 or less
Why ? No money involved, cure is not an option for the pharma industry.
And the researching want endless money funding to keep the research forever.
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Seems contradictory to some statements that there was a significant step forward in knowledge regarding PFS achieved by this study. If they had just collected the data a couple of month ago, how can you know that?
Anyway, @axolotl seems to be in the dark about this development (study being published in two parts), or at least isnt revealing anything. 
Lets hope its not true.
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I didn’t said that they collected the data 2 months ago, I said that around 2 months ago when I visit Khera he told me that they just finished to collect the data to start comparing it.
The sample were collected from the skin to analyze the genes, he told me this in a previous appointment.
The Italian study the finding was in the spinal fluid.
Thats what I wanted to say. If they had just finished the process of collecting the data 2 months ago, how can people on here claim many months ago that there was a significant knowledge gain? It seems contradictory.
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thats literally what i said.
last year some guy said there was significant genetics finding that delayed the study.
Maybe that guy is who was speculating.
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And yet he turned out to be accurate in his speculations of delay as well as a few other things when it related to other studies.
Let’s see how accurate you are with all the things you’ve claimed. If you’re right, I won’t doubt you again
The first part of the study is done, there is not delay, it is only waiting for the approval for publication. All this from Khera mouth.
Also he told me that the study is not intend to look for the cure and they are going to look into 7000 genes to find the cause.
If this were the case I would expect the Foundation who is funding the study would have been informed. Not that I doubt your account of speaking to Khera, @MOONCHILD.