Going back to an old post
Abstract 1052: Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation
http://cancerres.aacrjournals.org/content/75/15_Supplement/1052.short
Induction of inflammation with lipopolysaccharide (LPS) stimulated the TNFR1/NF-κB/IL-6/DNMT1 pathway, leading to hypermethylation of the SRD5A2 promoter and silencing of SRD5A2, while treatment with both LPS and TNF-alpha inhibitor reversed this pathway and reactivated SRD5A2 .
As you can see LPS and TNF-alpha inhibitor reversed this pathway and reactivated SRD5A2
Now Methylprednisolone the same medication that was administrated to Anonymous is a potent LPS and TNF-alpha inhibitor ** we talked about this before.
Lipopolysaccharide (LPS) stimulated the TNFR1/NF-κB/IL-6/DNMT1 pathway, leading to hypermethylation of the SRD5A2 promoter and silencing of SRD5A2
Now: Histone deacetylase inhibitors (HDACi) suppress inducibility of nuclear factor-κB (NF-kB) by tumor necrosis factor-α receptor-1 (TNFR1) downregulation.
http://cancerres.aacrjournals.org/content/66/8_Supplement/322.1
Histone deacetylase inhibitors suppress (IL-6) production by rheumatoid arthritis firoblast-like synoviocytes and macrophages via modulation of mRNA stability rather than blockade of NF-κB signalling
HDACs, has also been shown to reactivate methylation-silenced genes even in the absence of DNMT inhibitors
I don’t know guys what you think, but I think that we are getting close, we maybe can find the solution before the study is released. lol I am sorry for being a little SARCASTIC…