Cyproheptadine treatment of ED

#1
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Wiped out my Serotonin...resulted in Erection
#2

I could give this a try. I read a bit about it, it’s said to make you sleepy, so at least it might help me sleep if nothing else.

#3

Got very hard erections after taking it one day.
I really doubt the problem is 5AR related.

#4

Did you get any side effect from it?

#5

No. But it can screw neurotransmitter balance as its been trialed as antipsychotic and it depletes your serotonin and other neurotrasmitters. And of course there are other possible side effects. And it’s sedative, only take it before going to sleep.

#6

Are ypu going to keep taking it?

#7

I am still taking it, and its a huge breakthrough for me in terms of erection quality. Erections are back 80-100%. Some improvements in libido , but its still lacking. It could be serotonin and E2 balance thats playing a role. Serotonin is also dependant on E2 levels, which I have above normal. The fact is at the moment the strength of erections are pre PAS. But still no morning wood. I have occasional morning wood when it feels like i want to urinate, but its doesnt feel natural like pre pas. Besides that, sensation feels normal. Cyproheptadine is antagonist of 5HT2A, 5HT2C and 5HT2B. Some theory sugggests its only 5HT2C thats responsible for possible sexual dysfunction. So it might be better to try selective inverse agonist of 5HT2C instead of bombarding all receptors.

#8

Little update. Done some more research. I can tell that my erection was very hard while on cyproheptadine and I could maintain it longer than pre PAS, even without physical stimulation. I stopped the med and the effect is diminishing unfortunately. But I will try more selective drug in the near future, because cypro bombarding too many unnecessary receptors. There is also evidence isotretinoin is upregulating 5HT1A, which has a negative effect on Sexual behaviour.
I am interested particularly in 5HT1A and 5HT2C due to following reasons:

Downregulation of 5HT1A revereses ED.

The present study demonstrates that adjunctive treatment with a 5-HT1A antagonist not only can reverse SSRI-induced sexual dysfunction, but may also prevent these side-effects when co-administered with a SSRI.

Upregulation of 5HT2C induces erection.

Activation of 5-HT2C receptor subtype has been reported to mediate numerous effects, such as penile erection.[42][43] Based on multiple studies, results show that several 5-HT2C receptor agonists, including mCPP and YM348 induce penile erections in rats,[44] but mCPP seems to mimic both vasodilation and vasoconstriction. The vasodilator action is mediated by 5-HT1D receptors, whereas the vasoconstriction effect involves 5-HT2 receptor activation…
https://en.wikipedia.org/wiki/5-HT2C_receptor_agonist#cite_note-Bagdy_1992-42

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#9

I know everyone is obsessed about tribulus now, but I would say you should look into 5ht1c , 5ht1a theory. I had to stop periactin because i have upcoming surgery soon (not related to pas). But it was so far the best results I ever had , from everything I ever tried. Erection was super strong and I was little shocked from this change, because i didn’t expect it. literally improved from40- 50% to 110% .This med is available over the counter… its antihistamine. who knows it might bring a positive changes to more people and it would be possible to draw some conclusions…

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#10

Any sensitivity improvements? 110% erections don’t matter a whole lot when everything is numb

#11

My sensitivity problem wansn’t that bad, weirdly tribulus was making it worse, but my penis felt absolutely normal while on periactin, except that I was still lacking a bit of libido, but arousal time from porn was very fast. If i go into details, I was able to walk around the room with a boner without any stimulation and keep it up. And it was something absolutely new for me.

Moreover its proved isotretinoin is dysregulating 5ht1c, 5ht1a.

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#12

What about Yohimbine?

#13

5HT1A involvement in sexual function

5-HT1A subtype is involved in controlling both behavioral and hormonal indices of sexual arousal in male mice, while the 5-HT1B receptors antagonise sexual motivation, but do not modify the hypothalamic-pituitary-testicular response.

And study proving 5ht1a dysregualation.

#14

5ht1a upregulation is a common factor in SSRI and isotretinoin

The results demonstrate that fluoxetine may increase neurogenesis via the GSK-3β/β-catenin signaling pathway that links postsynaptic 5-HT1A receptor activation.

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#15

It’s partial 5HT1A agonist and we dont want to upregulate it.

It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and dopamine D2, and as a partial agonist at 5-HT1A.[32][34][35][36] Yohimbine interacts with serotonin and dopamine receptors in high concentrations.[37]

#16

I am after surgery and trying periactin again.After 4 pills throughout the day got the same extremely positive response. I have super hard erections when aroused. And I can maintain erection much longer than usually. And again… from somewhere 40-50% went to 100%.

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#17

how many mg are you taking in total? Do you only notice effects from taking 4 pills? Or do you notice effects at lower dosages as well?

I recent experimented with cypro and I didnt notice any changes when I took one or two pills (4 or 8 mg I think), it just made me really really tired but it didnt do anything for my erections

#19

4mg 3-4 times per day. Try taking it for 2 days. If you won’t notice any result on a third day. probably it doesnt work. And yes , unfortunately its very sedative, I just stay home and can’t do any activity.

#20

What surgery? Does it make you depressed since it drops serotonin?

#21

I will tell my story guys… Problem is that I can’t continue with this treatment , because few months ago I screwed my brain with l-dopa. Cyproheptadine is helping me 100%, but at the same time its making worse l-dopa condition. And I am forced to take 5ht1a , 5ht1b agonists now to keep my head in normal state. when I take these agonists (usually its SSRI meds), my ED basically dropping back to 40-50%. To be brief my condition is mimicking so called ‘’ l-dopa induced diskenisia in Parkinson patients’’ . The only difference is that i dont have dyskenisia/parkinson, but underlying mechanism of 5ht system disruption is the same. I have persistent brain electrification on the left side of the head(most likely striatum). And electrical jolts are hitting this localised area continuously as well as I have some localized brain/head muscle contraction of unknown nature. It can be controlled easily with few SSRI pills without need of further administration. But anything thats acting on dopamine and serotonin receptors can make it worse and create a storm in my head. I have ideas of alternative treatment of this condition and once it solved(hopefully) I could go back to returning my erection. For me its pretty clear that the problem is within 5ht1a receptor. I can improve my ed anytime now, but it will make worse ldopa condition.

Another thought why its helping is that I might have post ssri on the top of PAS. Because I was recovered for 6 months and one day stupidly have taken dapoxetine, which may have contributed to crash.