Current research is not paying enough attention to what is going on in terms of penile tissues.
In my case, this was the reason why the symptoms were persistent after I stopped finasteride.
Depression, insomnia and other typical sides came as a consequence (I started to see fewer people, to stress a lot, to worry about the future, libido became very low, I was seeing attractive women and I didn’t understand why nothing was happening in my body as a result, which gave me a lot of anxiety, etc.).
I knew something had changed in the erections mechanism (hourglass shape in pre-erect state, blood flowing well in the proximal part of the penis but slowly in the distal part, etc.), but it was difficult to understand how/why.
At the same time, doctors tended to say “it’s all in your mind”, which made the side effects worse.
The only doctor that was honest enough said “we don’t know what is happening” and he suggested that I took low dose Taladafil 5mg (Cialis or other brands) for at least 6 months.
I immediately got better erections but sensitivity was missing. Now, after 1 year, sensitivity is coming back, slowly. Strangely, the tissue seems to be healing from the top (glans) to the midshaft (I would have expected to start from the midshaft to the glans, since the proximal part is fine).
That doctor said that he supposed all this was related to some kind of contracture (high adrenergic tone) of the penis that takes a long time to heal.
So: I think it’s good that current research on PFS analyzes epigenetics, gut flora, neurotransmitters, androgen receptors, etc.
But if we don’t pay attention to the histological changes (tissues) happening in the penis, we may be making a huge mistake and wasting a lot of time.