“With the advent of novel CRISPR tools, we may now sit on the cusp of a revolution in our ability to probe epigenetic alterations in both a site-specific and high-throughput manner. With this in mind, many fundamental questions regarding how epigenetics causally alter cellular function across the diverse range of epigenomic contexts may finally be answered. This advancement in knowledge will provide novel cellular engineering modalities, allowing for the co-option of existing epigenetic pathways in the cell to unlock applications involving stable, wide-ranging, inheritable and reversible changes in gene expression. This has the potential to revolutionise gene therapy approaches to precisely sculpt biological function and to improve human health.”
This article was written exactly 2 years ago. Much has advanced since then.