Based on these studies, do you think we would get better or worse using Clostridium Butyricum? In my humble opinion and with all my ignorance on the subject, I think Butyrate produced by Clostridium Butyricum could help us, but I could be wrong.
Follow the studies for the experts.
https://new.hindawi.com/journals/bmri/2015/412946/
There are many others recent studies about that.
Perhaps it’s not enough to post two links and say “in my opinion…” and then expect someone to research and read into your idea. Perhaps you should explain how you came to the conclusion. You’re expecting someone to put more effort into answering your question than you’re putting into asking it.
I don’t mean to criticise you but making it as easy as possible for you to get help with your problem would make it more likely.
We don’t have many “science guys” but we have plenty of theories.
Yes, I have followed these studies for a while.
It is the butyric acid. Butyric acid has anti-bacterial, anti-inflammatory, anti-cancer, neuroprotective properties and cardio-protective properties (https://link.springer.com/article/10.1007/s00424-019-02322-y).
These effects seem to be mediated by epigenetic changes that as histone deacetylase inhibitor https://en.wikipedia.org/wiki/Histone_deacetylase, https://en.wikipedia.org/wiki/Butyric_acid
The production of butyric acid is not specific to Clostridium Butyricum, but also by * Clostridium kluyveri
These are bacteria that are that naturally occurring in your gut. They use fiber like resistant starch, pectin and other kinds of fiber to produce butryic acid.
It is true that butyric acid is one of the most hopefull compounds in the fight against dementia, other neurodegenerative diseases and colon cancer (especially FAP).
As PFS and PSSD also fall in the group of neurodegenerative diseases and as PFS also has vacular and cancer risks I understand why you are interested in the compound. Also there had been a study that showed that PFS patients have microbiome issues (probably the same for PSSD).
The field of microbiotic studies is relatively young. A and healthy (diverse) microbiome produces a sufficient butyric acid.
Now keep in mind if you ad single strains of microbes to your gut, this is like an invasion of billions of bacteria that your gut maybe is not prepared for. A healthy microbiome is balanced and consists of many different strains. I would say it is too early to say if probiotika really are safe and efficient. There had been also studies that people after antibiotics better recover their microbiome with prebiotics and not with probiotics.
Prebiotics are fiber rich foods. Like untreated wholefoods, berrries, whole grains, inulin-rich vegetables like onions, garlic, broccoli, chicory…
I am following the microbiome research and preventive medicine. IMO prebiotics are at least as effective, safer, and a lot cheaper.
Nice answer! Thank you for that. Do you have any product recommendations with prebiotic complex + enzymes?
No, I don’t but. Most green foods that contain a lot of fiber are a good choice.
I just saw, that butyric acid also acts on the 5-alpha-reductase as an inhibitor (as many common daily used plant compounds do). So there may be a bit of caution too. But that accounts for most spices too.
I’m wondering if that’s why I’ve experience negative effects from sodium butyrate?
Difficult to say, yes it is a natural 5a-reductase inhibitor. But there are many spices and evel ALA fatty acids which have similar effects