Cork research highlights role for bacteria in the fight against viruses

General Discussion
#1

Im not recommending this particular strain atm, but its interesting nonetheless and for the fact that it was given intranasally. Just published this month.

Scientists in Cork have discovered a naturally occurring bacterium that can help reduce the damage inflicted on the human body by respiratory viruses such as influenza.

The findings show that two different Bifidobacterium longum strains (35624® and PB-VIR™) given via the nose, protected mice from lung injury and significantly improved survival from influenza.

Dr Groeger says the study showed that “the protective effect was demonstrated by multiple different objective measures of inflammation, but the most impressive evidence was the reduction in mortality.” The scientists went further and showed that the beneficial effects were due to a component of the bacterial cell wall which is sensed by the body’s immune system.

This inhibits the cytokine storm and serious inflammatory damage associated with respiratory viruses.

Heres the actual study.

#2

Looking at this a little more, here propionibacterium is again.

Nasal microbiota composition
Most ubiquitous bacterial taxa are:
• Corynebacterium (88.2%)
• Propionibacterium acnes (83.7%)
• Staphylococcus epidermidis (90.4%)

Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis

P. acnes might be commensal not only to the skin, conjunctivae, and intestine, but also to the lungs and lymph nodes of individuals without sarcoidosis.

You could almost say propionibacterium might be the most common and abundant bacteria outside of the gi tract. Its also a common contaminant because of its abundance.

in a recent meta-analysis of published 16S rRNA gene sequence data, Mackenzie et al. suggested that Burkholderia and Propionibacterium may be gatekeepers that stabilize the healthy bacterial community, as the removal of these genera from healthy datasets resulted in more fragmented networks that were potentially more susceptible to disturbance

# Chronic Rhinosinusitis: Potential Role of Microbial Dysbiosis and Recommendations for Sampling Sites

#3

Just to repeat this statement,
"P. acnes is the most common commensal bacterium in the lungs and lymph nodes."
Makes you wonder if propionibacterium is involved in immune response and mobilization when its showing up in lymph nodes.

Looking at a possible cause and effect here,

Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics against Methicillin-Resistant Staphylococcus aureus

Isotretinoin and Staphylococcus aureus Infection A Possible Association

Although significant dysfunction of the immune system has not been demonstrated with isotretinoin, nasal colonization with S aureus has been shown to occur.

The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris

There was statistically significant difference between two groups in means of alteration of the microbial flora (P = 0.013). The difference was definitely observed among nasal cultures (65%) in isotretinoin group and fecal cultures (20%) in the other. Staphylococcus aureus colonization was prominent in the microbial floras of nose and oropharynx and 2 of 14 nasal isolates were detected to be methicilline resistant while Escherichia coli with extended spectrum beta lactamase activity was detected in fecal floras of patients in isotretinoin group.

#4

Adding to this, I know there have been alot that have mentioned sinus problems and ear fullness in both PFS and PAS, myself included.

Bacterial community collapse: a meta‐analysis of the sinonasal microbiota in chronic rhinosinusitis

https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1462-2920.13632
November 2016
The meta‐analysis results suggest that the bacterial community associated with CRS patients is dysbiotic and ecological networks fostering healthy communities are fragmented. Increased dispersion of bacterial communities, significantly lower bacterial diversity, and increased abundance of members of the genus Corynebacterium are associated with CRS. Increased relative abundance and diversity of other members belonging to the phylum Actinobacteria and members from the genera Propionibacterium differentiated healthy sinuses from those that were chronically inflamed.
whose presence may be important in maintaining a stable sinonasal bacterial community

^maybe this could apply elsewhere in the body as well.