Contraceptives and libido loss and estradiol

General Discussion
#1

We evaluated 36 studies (1978-2011; 13,673 women). Of the COC users (n = 8,422), 85% reported an increase (n = 1,826) or no change (n = 5,358) in libido and 15% reported a decrease (n = 1,238). We found no significant difference in sexual desire in the case of COCs with 20-35 μg ethinylestradiol; libido decreased only with pills containing 15 μg ethinylestradiol.

CONCLUSIONS:
The majority of COC users report no significant change in libido although in most studies a decline in plasma levels of free testosterone and an increase in those of sex hormone binding globulin were observed.

#2

Abstract
INTRODUCTION:
Oral contraceptives (OCs) induce mood and libido changes.

AIM:
The aim of this study was to evaluate in young, eumenorrheic, healthy women the sexual behavior and the genital vascular effects of an OC containing 30 µg ethinylestradiol (EE) and 3 mg drospirenone (DRSP).

MAIN OUTCOME MEASURES:
The main outcome measures are McCoy Female Sexuality Questionnaire (MFSQ), the labia minora thickness and vaginal introitus area, the pulsatility index (PI) of clitoral and labia minora arteries, and hormonal and biochemical assays.

METHODS:
Twenty-two adult, eumenorrheic, healthy women were administered the two-factor Italian MFSQ. The labia minora thickness was studied by two-dimensional ultrasonographic, and the clitoral and labia minora arteries were evaluated by color Doppler; three-dimensional static volumes of the vulvar area were calculated. Hormonal (estradiol, androstenedione, and testosterone) and biohumoral (sex hormone binding globulin) parameters were assayed. Subjects were studied in baseline conditions and after 3 months of therapy with an OC (Yasmin®, Bayer-Schering Italia, Milan, Italy; -30 µg EE + 3 mg DRSP).

RESULTS:
After 3-month treatment, the labia minora thickness and the vaginal introitus area significantly decreased in comparison with the baseline values, whereas the PI of the dorsal clitoral artery and the posterior labial artery significantly increased. The OC use induced a significant decrease of the two-factor Italian MFSQ score, a reduction of the number of intercourse/week, and a reduction of the frequency of orgasm during intercourse. The item 18 (pain during intercourse) worsened after OC.

CONCLUSIONS:
The treatment with Yasmin® (Bayer-Schering Italia) is associated with increased pain during intercourse, with decreased libido and spontaneous arousability, and with diminished frequency of sexual intercourse and orgasm.

#3

gender-id.com/TSInfo/estroeff.htm

In this study of men takin estradiol it shows their spontainous errections were lost with estradiol.

#4

yup, imagine if we took something that basically wiped out any protective effects from estrogen, or someting even more insidious than estrogen dominance, something called unopposed estrogen. Not just minor changes in erectile strength and libido, but major drastic changes. Changes that can come form one simple pill. One pill that can immediately wipe out erection strength and cause almost instantaneous testicle pain. Its starting to come together.

#5

Are you saying estradiol results in testicular pain? I am trying to work out why many get testicular pain on fin and if this could be a good indicator of some kind of damage being done or changes being made.

I do no read many reports of people having testicular pain on HCG or when they go on TRT without HCg? Maybe there are some but it seems far from common? What about guys on a cycle when there testies srhink - do they report pain?

#6

I have heard anectodal reports of bodybuilders having testicular pain from high estrogen until they take a aromatase inhibitor.

#7

I never have seen that. I never got testicle pains on fin but a few yeears after I took erase and got a pain right where there was a nodule on my nut. I do not exactly know when that nodule appeared.

#8

was it left testicle pain?

#9

Yes right on a bump which kind of feels like a grain of rice or matchead. So painful I could not ride a motorbike. At first the erase brought my libido back but by the time the pains kicked in the benefits were gone.

#10

It is really astonishing that we are only now asking why female libido gets messed up on the pill. All drugs have side effects and that is the price you pay for not getting pregnant. There are no pills to that make generally healthy people more healthy. This is the main problem with the pharma industry. They seek drugs that can be bought by billions of people, but there really aren’t billions of severely ill people… Instead iatrogenic illness sets in. Some people are severly ill and need more interventions, but most of our modern illness are really lifestyle problems like diabetes. TGEL is a performance gimmick. Very few people have low t that they are simply crippled. Aids patients do. No doubt Propecia can cause iatrogenic harm for some. Question is how do you treat it without a band aid

#11

I think millions have low T and the effects are crippling and life threatening www.thehidddendisease.com