Composition comprising rutin and polyunsaturated fatty acid having an inhibitory activity on 5 alpha-reductase


At this point, it is possible to calculate the inhibition percentage of 5-alpha-reductase. The result is expressed as the experimental average measured. The overall experimental error is estimated at as being not higher than 10%.

The % of activity of 5-alpha-reductase is calculated with respect to the control non-treated with the substance being examined: reduction % = [average absorbance Ctrl - average absorbance treated product] /average absorbance Ctrl*100 RESULTS

Figure imgf000023_0001

The results show that among the substances tested, the mixture of omega-6 polyunsaturated fatty acids with rutin proves to be more effective than the Boehmeria extract in inhibiting the activity of 5-alpha-reductase enzyme with a maximum activity at 48 hours (-32.8%) .

The effect of Boehmeria and of the mixture of omega- 6 polyunsaturated fatty acids with rutin is established more rapidly with respect to the positive control, consisting of Serenoa repens.

According to the study, Rutin is worse than the Serenoa Repens.