Chronic sleep deprivation desensitizes 5ht1a receptors in mice.
8 days of sleep deprivation lead to a desentization of 5ht1a which takes 7 days of. Recovery sleep to come back to normal.
After insomnia comes into PFS it probably induces other changes like this desentization of 5ht1a…that by itself means less dopamine and dysregulation of hpa axis. Afiu…
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