Has anyone of you been on chemotherapy (cytotoxic) after developing PFS?
Why do you ask?
Is it something your having to go on and if so, why?
I believe that most of the reductase enzymes haven’t been replaced like they should after stopping treatment with Propecia. Finasteride is an irreversible inhibitor, and failure to replace the defect enzymes may be the root cause. Cytotoxic chemotherapy will damage the cells, force the body to replace them, and hopefully include 5AR Type 2 enzymes in the process.
Consider this; I’m currently on a very large dose of testosterone. Arimidex is included in my protocol as well, but yet - I don’t feel much androgenic effects! I feel the testosterone, and Arimidex improves my symptoms, but that’s it! However, AAS that don’t aromatize, like androstanolone (Andractim), mesterolone (Proviron) and methenolone (Primobolan), gives me a lot of androgenic effects.
Cytotoxic chemotherapy is used to treat immune diseases.
Enden, what androgenic affects do you believe have been improved?
Ended
Can I ask you about your TRT?
I am just about to possibly go down this route since my T level is only 6.9 nmol
May I ask you about your experiences with TRT alone?
Also, what improvement you have seen?
What is your T level now?
This thread isn’t about TRT, but I’ll answer your questions anyway. When I’m talking about androgenic effects, I’m thinking of a general feeling of well-being, psychological- and physical strength, aggression, growth of body hair (I can literally feel my beard grow), aggravated hair loss and seborrheic dermatitis - and of course significant improvement in sexual function; I’m talking about high libido and erection quality. I also have morning erections on those days, and increased amount of prostate/seminal vesicle fluid is observed now and then. However, I’ve been unable to stabilize condition. Keep in mind that this is on a combination of medications, and a testosterone level within the normal range. Testosterone injections alone makes all the symptoms of PFS worse.
200 mg TE a week puts my testosterone level on around 90 nmol/l (normal range 8 - 35). I’m currently on 500 mg a week, including a significant amount of Nebido that’s about to be washed out, so you take a guess.
Hi
Thanks for your reply.
What was your T level before starting TRT?
Surely your happy with 90nmol???
What else would you suggest I use in combination with TRT?
Do you manage to function pretty well nowadays?
enden why do you think chemotherapy will make the body replace the defected enzym?
The enzymes are located within the cells, and if they haven’t been replaced like they should - say that the enzymes are defect because finasteride is still bound to them (it is possible because it’s an irreversible inhibitor) - using chemotherapy to damage the cells, is likely to cause the body to replace the enzymes as well, when it’s replacing the cells.
My TT was 11 nmol/l before I began TRT. My FT was low as well. 90 nmol/l is way too high. It’s not TRT. The TT shouldn’t exceed the normal range, and it shouldn’t go too low either. What’s low, depends on your symptoms. Arimidex is going to be essential if you decide to go on TRT. I’m using 2.5 mg Cialis a day too, because DHT deficiency leads to NO/cGMP deficiency. Cialis causes cGMP to accumulate - and it helps improve erection quality on good days.
Enden, would you conclude that mesterolone (Proviron) has had a positive effect on your symptoms?
My total testosterone is fine. My SHGB (70 nmol, range is 20-60) is hugely elevated however, and thus my free testosterone is low.
A cursory search found Proviron to be the primary treatment for reducing SHGB. Do you think it’s worth a go?
bump.
No seriously,has anyone undergone a chemo after pfs?
tnx
Yea, I was on a pretty harsh course of chemotherapy – cisplatin, etoposide, and bleomycin at the same time. It did not change anything with regards to PFS. Killed the cancer, though.
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