I just read about the protein CHD8, which was never mentioned on this forum.
I wonder if this protein plays a critical role in why the gene expression of our ARs are messed up and if there is a way to alter this protein to effect gene expression:
" CHD8 is required for androgen-induced cell proliferation
Our results indicate that CHD8 is required for the optimal transcriptional activation of the TMPRSS2 gene upon induction by DHT and that CHD8 is required for the appropriate androgen-responsive recruitment of AR to target promoters. Therefore, it is likely that CHD8 plays an important role in androgen-dependent cell growth of LNCaP cells."