Central dopamine is a key neurotransmitter in the control of sexual function, Drug induced Parkinsons?

General Discussion
#1

Im sure this isnt new. I could quickly link Accutane, ssri’s and 5ar inhibitors.
i’m also wondering about a drug induced type of Parkinsons. I found this, at first I thought it was the same guy.
Apparently gi complaints can be a big feature as well along with loss of autonomic functions.

Isotretinoin may affect dopaminergic neurotransmission by disrupting the structure of dopamine receptors and decreasing dopaminergic activity. The dopaminergic system is implicated in numerous psychological disorders, including depression.

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Accutane? Parkinson’s - Young Onset Forum - Parkinson’s Foundation …

](https://forum.parkinson.org/topic/9336-accutane-parkinsons/)

Aug 7, 2010 - 3 posts - ‎2 authors

Hey All, Anybody ever take the drug accutane . I did when I was younger way back in the early 80s. Sometimes you just cant help and wonder if …

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forum.parkinsons.org.uk › Research › Research discussion

Parkinson and Roaccutane - Research discussion - Parkinson’s UK Forum

](https://forum.parkinsons.org.uk/t/parkinson-and-roaccutane/21872)

Dec 2, 2019 - Hi All, Anybody ever take the drug accutane . I did when I was younger . Sometimes you just wonder if something you took or tried or did caused …

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#2

It’s clear that in many of us the problem is related to an imbalance in neurotransmitters.
In my case, I have a constant spasm in some pelvic muscles and in the middle of the penis. It’s not Peyronie, but a strange contracture (that I managed to control using a vacuum erectile device during a few months).
So I guess it’s related to some dopamine impairement. Just like Parkinson, which also produces spasms in certain muscles.

#3

Maybe keep this in mind. I tested positive for the acetylcholine ganglionic neuronal antibody mentioned in the following study.

Best evidence yet that Parkinson’s could be autoimmune disease

Read more: https://www.newscientist.com/article/mg23431314-900-best-evidence-yet-that-parkinsons-could-be-autoimmune-disease/#ixzz6CkyGkT62

A case of Parkinson’s disease following autoimmune autonomic ganglionopathy

published:13 March 2019

The patient is an 80‐year‐old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti‐ganglionic acetylcholine receptor (anti‐gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti‐gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson’s disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti‐gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.

#4

https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12653#

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