@whathaveidone4669,
You wanted to know what happens when “safer” medications like Breezula come out, here is your answer.
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I read on hair loss talk of people having side effects from breezula too. Some guy said his shoulders got smaller and another guy said his libido was weaker. Same story like you they got the chemical earlier. They didn’t indicate whether they got theirs tested at a lab though.
I’m skeptical that it probably doesn’t matter and really suspicious that Cassiopeia the company is lying about no side effects from this drug. That topical finasteride company lied the same way too.
Let us know about your own lab test purity though. It could be that Science Bio company just sold you finasteride.
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What time did you get your bloodwork? I did quick scan and these are my findings:
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Lowish E2 (19 pg/ml). You’re in the low E2 subset. If your post treatment level is lower, which I suspect to be the case since your T is lower, then this may explain your libido issue.
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Lowish Cortisol (12.7 ug/dl) especially if this is in the morning when cortisol is highest. Check your post treatment level.
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5AR or not it’s still an anti androgen and can give you the same shitty condition as PFS. I never even used finasteride and landed myself here thinking I was safe.
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If Breezula doesn’t lower DHT like they claim then DHT has nothing to do with our issues. But it probably does lower DHT, just another lie.
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It’s a steroidal AR antagonist, meaning CB binds to the AR inside the cell cytoplasm, and blocks the usual AR signaling pathway. It’s hard to find data on CB besides wiki, but the binding affinity for AR is supposed to be lower than testosterone, so less powerful than ru58841. This is why people have dismissed CB as a weak anti-androgen; yet, the company Cassiopea claims that it competes for AR with DHT, which seems likely given that the sides I’ve experienced are the same one would get in a state of androgen deprivation.
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Yeah. CB would theoretically be superior to other anti-androgens currently available if it didn’t go systemic like Cassiopea claims; however, it now may potentially be more dangerous than finasteride, given that it blocks AR from T and DHT. May I ask, what AA did you take?
To be honest, I don’t have libido issues whatsoever. My libido is unaffected. For the cortisol - that was AM cortisol, so yes. I will be checking. I’ve been trying to get ACTH (Adrenocorticotropic hormone) checked but no labs I’ve ordered blood from check it. ACTH abnormality would be most pertinent for my situation because it was the marker used to determine HPA axis suppression in patients who underwent the 1% acne (Winlevi) trials.
It could also be something like RU, flutamide, enzalutamide, spiro, etc. I have not had any changes to my face, shoulders, or any other body parts.
I took one for the team, as they say.
Right. If it turns out to be pure CB, then my personal theory is that CB doesn’t rapidly hydrolyze into cortexelone (cortisol precursor); rather, it enters circulation and binds to AR in tissue at a rate faster than hydrolization, making it unsafe and no different than flutamide.
Just curious but if you’ve waited this long not trying finasteride, what made you try clascoterone without waiting for it to go public and waiting to see if people posted online about side effects?
The company is probably pulling the same shit Merck did and trying to get the drug approved and then later they know they’ll have to admit the trials participants had permanent side effects.
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I read the trials for CB for treating acne and mpb. Both trials were published stating no adverse sexual side effects, besides HPA suppression (which reversed after 4 weeks of stopping treatment). I’m also considering HPA suppression as a contributor to my situation.
I also read the experiences of a handful of users on hairlosstalk/baldtruth. Most did not document sexual sides, but rather things related to elevated cortisol. I didn’t want to use a chemical that went systemic to a large degree like finasteride, hence why I opted for CB, because of its purported safety profile.
Just wanted to update everybody. I’ve been taking clomid 25mg EOD, cialis 5mg, and 1mg anastrozole twice/week. I had my labs checked again: total T came out to 422, E2 was 40. If I’m not mistaken, the clomid and cialis together were ever so steadily bringing my penis back to life, until today, when I made a huge mistake. The clomid has been giving me a bit of an inflammation on my scalp, so I decided to use my ketoconazole shampoo (which contains saw palmetto) to relieve the itchiness. Lo and behold, a few hours later I had testicular pain. Two weeks of progress gone. Moreover, my penis is morphing badly again -hourglassing, hard-flaccid, shriveling.
I actually can’t believe this shit. So far I’ve read a few people say they’ve experienced crashes on shampoos like Regenepure. I’ll speak to my doctor about this, but is it really possible that saw palmetto via shampoo caused me to “crash” again?
Edit: I had no problems with this shampoo before experiencing sides on CB-03-01.
Did you get the CB tested?
Yea it’s possible you can crash from saw palmetto shampoo. It’s weaker but you’re probably more susceptible now than before you took CB.
Read my story and you’ll see what regenepure dr did to me don’t think your safe using topicals I used it for years without any issue then slowly got the side effects and crashed severely.
Not yet. I will eventually but I’m too busy with school at the moment. But the moment I send it off to get tested I will let you know.
Hey everybody,
So I ended up stopping the clomid + anastrozole because I was experiencing pretty bad mood swings, subtle brain fog, and blurry vision. Moreover, both clomid and anastrozole caused pretty severe scalp inflammation, which was actually unbearable. I couldn’t even touch my hair without my scalp burning like crazy. I also wasn’t really comfortable with lowering my estrogen because I never felt like it was suboptimal for me, as I’ve maintained good libido and erectile quality (although I haven’t gone a day without cialis). Additionally, my new labs are:
Testosterone (total): 1,205 ng/dL
DHT: 83 ng/dL
LH: 10.1 mIU/mL
FSH: 5.7 mIU/mL
E2: 31.1 pg/mL
SHBG: 41.3 nmol/L
To be honest I was not expecting my T to be this high after only 2 weeks of treatment (I even skipped some doses). Having that much T really didn’t feel that great for me, which could be because of the high SHBG. Anyways, my issue at this point is not a lack of androgens, but rather structural.
I went and saw a proper urologist who specializes in pfs. After performing the ultrasound they found diffuse fibrosis in my penis. Not full blown plaque, but fibrosis scattered in the corpus cavernosum, particularly the left side. I was more relieved than shocked, because at this point I’m just mentally exhausted from this whole situation. I went so far into handling my hair loss that for the first time in my life, I damaged my body significantly. So far it’s been painless, but I imagine things could’ve gotten a lot worse had I ignored the signs of structural damage (hourglassing, shrinkage, etc.).
In regards to treatment, I will be doing shockwave therapy. I know there has been mixed success with this modality of treatment, since it’s quite experimental and cost-prohibitive, but I really want to find a cure for myself so I can find some peace and move on with my life. My erections are quite good with cialis, but I’ve lost a bit of girth, and I attribute that to the mild fibrosis that is probably restricting blood flow. As for the “hourglassing,” the doctor told me that because it’s not present during full erection, then it’s not caused by the fibrosis, but I’m a little apprehensive about this still. The shape is present just before a full erection and when I’m flaccid or semi-flaccid. It’s also exacerbated by bowel movement and when I contract my penis. It’s not the end of the world, but it’s still quite annoying and worrisome. I’m hoping that it may go away with the shockwave treatment, but since it’s not a functional issue but rather cosmetic, then it shouldn’t be a top priority right now. Does anybody have knowledge on the hourglass shape? I know there is a difference in the underlying issue depending on whether it’s present in the fully erect versus flaccid state. Same goes for the loose scrotum. He said that down the line I could see a plastic surgeon for it if it really bothered me. It does, but we’ll see if this one recovers naturally. I will post an update after the shockwave treatments. Let me know if anybody has any questions, I’d be happy to answer them.
@tgfbeta I have the same physical symptoms (girth loss, curvature, hourglassing) but NO fibrosis. Did multiple imaging tests and they found nothing. So maybe something else is causing the same issues with you instead?
I am suffering from the same symptoms as you.
may i get your email???.. i really want to know and heard from you
what can i. do …
best regard