Can someone get this test done?

[bryce54]

This thing is a beast, look what it covers:

The ONE - Optimal Nutrition Evaluation - consists of:

Metabolic Analysis measuring 39 key organic acids to evaluate gastrointestinal function,methylation, cellular energy production, neurotransmitter processing, and functional need for vitamins, minerals, and co-factors.

Amino Acid Analysis measuring 38 amino acids to evaluate dietary protein adequacy, digestion, absorption, amino acid transport, metabolic impairments, and nutritional deficits; including essential vitamins, minerals, and amino acids.

Oxidative Stress Analysis is a sensitive tool to evaluate the body’s anti-oxidant reserves and the presence of oxidative injury.

If someone is able to afford it, PLEASE get this test done and share the results:
integrativepsychiatry.net/optimal_nutrition_evaluation.html

[spstriken]

will they give you a treatment?

[tim1911]

This test is obviously a scam.

[moonman1]

Got basically the same test done but through MetaMetrix

[bryce54]

@spstriken

will they give you a treatment?

they give you nutritional recommendations on what is wrong and what is missing and an insight into what is happening. the thing i’m very interested in is the methyladation process.

@moonman1

Got basically the same test done but through MetaMetrix

my jaw just dropped to the floor, high free radicals specifically

i’m going to look into the others. thanks for posting this.

[Lincoln28]

@moonman1

Got basically the same test done but through MetaMetrix

Hi moonman, did you already discuss these results on a different thread or post doctor’s comments? Cheers.

[moonman1]

@Lincoln28

@moonman1

Got basically the same test done but through MetaMetrix

Hi moonman, did you already discuss these results on a different thread or post doctor’s comments? Cheers.

Below is what she said…

=======================

Metametrix Organix Basic Profile

Methylation
I am not overmethylated or undermethylated. My folate was slightly low, but not enough to cause issues.

Neurotransmitters
Everything is in range. (even though I would say it looks less than optimal)

Fatty Acid Metabolism
Great

Carbohydrate Metabolism
Great

Mitochindrial / Energy Production
Great

B-Vitamins
Slight B-6 deficiency. Nothing that would cause issues though.

Lipid Peroxides
High. I can’t really remember what she said about this though.
What are Lipid Peroxides? In its effort to produce the chemical energy to power your cells and fight infection, your body makes harmful chemical called free radicals. Breakdown of you bodys cell metabolism by free radicals leads to the formation of lipid peroxides. Antioxidants prtect you against this process, and the lipid peroxide test tells you if you have enough of these antioxidansts in your system. High levels are associated with cancer, heart disease, stroke, and aging.

Spectracell LipoProtein Particle Profile
This test measures a bunch of stuff and seemed to be what she was most concerned with.

All of the following were fine
-CRP (highly sensitive)
-Homocysteine
-Insulin
-Total cholesterol
-HDL
-Triglycerides

Not so fine
Then it starts to get into a bunch of markers for the actual Lipoprotein Particles. This is were she said she was semi-concerned. My “small dense HDL particles” were off the charts high and some other cholesterol particles were highish. Also my Apo B-100 marker was high which “could be a genetic thing”. However none of this would explain my PFS symptoms…

[bryce54]

@moonman1

B-Vitamins
Slight B-6 deficiency. Nothing that would cause issues though.

Interesting I just read this because I just read this paragraph as soon I pulled up this thread:

Inhibitory neurotransmitters tend to inhibit firing of neurons. The most important of these is GABA, which is synthesised from Glutamine in the presence of Active Vitamin B6 (P5P). GABA is examined more on the Adrenal and Endocrine System page. Taurine is another, which performs many vital functions in the body, including nutritional metal transport into the cells. Taurine is examined in more detail on the Nutritional Deficiencies page. The third main inhibitory neurotransmitter is the amino acid L-Glycine.

Nitric Oxide Cycle, Superoxide and Peroxynitrite

If you check out that website… it talks a lot about NO and the free radical capabilities it has… I’m trying to piece this together…

I’m going to look more in depth into your test results on this.

[moonman1]

I was taking B6 drops and folate drops for a while that she Rxed, but it didn’t really help anything…

[moonman1]

After searching online, my results show…

Low Vanilmandelate
-can indicate adrenal exhaustion (yes)
-indicates imbalance in epinephrine and norepinephrine catabolism indicating a need for tyrosine
-indicating Epi- & Norepinephrine turnover inhibition
-recommends Phenylalanine and Tyrosine supplementation
-indicate an increased need for dopamine.

Low 5-Hydroxyindoleacetate
-can indicate untreated depression
-indicates low serotonin
-can lead to insomnia (no issues there for me)
-only measures TOTAL body metabolism and not brain metabolism

High Kynurenine + High Quinolinate + High Picolinate
-Indicates viral, fungal and/or bacterial infection (interesting as my crash came along with major illness)
-can create muscle soreness and sensitivity to light and sound
-can cause brain cells to die off

Mid-Low Homovallinate
-created from the breakdown of dopamine
-seems to be ok level, but not optimal

I really wish she would have ordered the gut dysbiosis test!
metametrix.com/test-menu/profiles/organic-acids/organix-dysbiosis
-Apparently a d-arabinitol test will show if candida is present. High levels will indicate so…

Interesting to say the least

[bryce54]

hey moonman, i remembered that you have free radicals that are high, have you ever tried any of these before?

There are many substances in the body which act as antioxidants, but the three most important frontline antioxidants are
Co-enzyme Q10. This is the most important antioxidant inside mitochondria and also a vital molecule in oxidative phosphorylation. Co-Q10 deficiency may also cause oxidative phosphorylation to go slow because it is the most important receiver and donater of electrons in oxidative phosphyylation. People with low levels of Co Q 10 have low levels of energy.
superoxide dismutase (SODase) is the most important super oxide scavenger in muscles (zinc and copper SODase inside cells, manganese SODase inside mitochondria and zinc and copper extracellular SODase outside cells) , and
glutathione peroxidase. This enzyme is dependent on selenium and glutathione, a 3 amino acid polypeptide, and a vital free radiical scaveneger in the blood stream.

All the above antioxidants can be measured and I now almost routinely measure the frontline antioxidants, i.e. Co-enzyme Q10, superoxide dismutase(SODase) and glutathione peroxidase.
Co-enzyme Q10 My experience is that levels in CFS sufferers are almost always down and that they can be corrected by taking Co-enzyme Q10 300mg daily for three months, after which continue with a maintenance dose of 100mg.
Superoxide dismutase (SODase). Deficiency can explain muscle pain and easy fatigability in some patients. SODase is dependent on copper, manganese and zinc and I would expect this to be maintained in people taking my physiological mix of minerals (MMMs). However, when there is a deficiency, these minerals are taken separately. Experience shows that the best results are achieved by copper 1 mg in the morning, manganese 3 mg midday and zinc 30 mg at night. Low dose SODase may also result from gene blockages and these are also looked at when the SODase test is done. Blockages are most often caused by toxic stress, such as heavy metals and pesticides.
Glutathione peroxidase (GSH-Px). This is made up of glutathione, combined with selenium. There is a particular demand in the body for glutathione. Not only is it required for GSH-Px, which is an important frontline antioxidant, but it is also required for the process of detoxification. Glutathione conjugation is a major route for excreting xenobiotics. This means that if there are demands in one department, then there may be depletions in another, so if there is excessive free radical stress, glutathione will be used up and therefore less will be available for detoxification and vice versa. Of course, in patients with chemical poisoning or other such xenobiotic stress, there will be problems in both departments, so it is very common to find deficiencies in glutathione: If there is a deficiency of GSH-Px, then I recommend that patients eat a high protein diet (which contains amino acids for endogenous synthesis of glutathione), take a glutathione supplement 250mg daily, together with selenium 200mcg daily (which is present in my physiological mix of minerals MMMs).

drmyhill.co.uk/wiki/Antioxidants

[moonman1]

I’ve used quit a few including CoQ10. I would prefer to take IV doses of anti-oxidents actually. But, what is the root cause of all this? I would rather treat that than treat symptoms.

[aj72]

I think it’s interesting your results showed high lipid peroxides, meaning high oxidative stress. This makes a total of four of us I’ve seen with some kind of marker of high oxidative stress. (Droit and I both have low reduced glutathione in plasma; and someone else reported “low glutathione”, probably “total whole blood”, a less useful but still suggestive marker.) I haven’t yet seen any kind of tests results showing a lack of oxidative stress.

Oxidative stress is kind of a vague, general concept in the body associated with a lot of different things; but one of them is inflammation and autoimmune diseases. (Of course, for all we know, androgen insufficiency/insensitivity may also cause it…)

[vincentv]

my test also showed higher levels of oxidative stress. High pyroglutamate.