cGMP-specific phosphodiesterase type 5 is an enzyme from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina.
Phosphodiesterase Type 5 - is an enzyme which is responsible for destroying cGMP. Viagra stops this enzyme, that equals more cGMP and therefore more erection.
phosphodiesterase type 5 – It is found in corpus cavernosum (Penile tubes) .
phosphodiesterase type 5 – it affects blood vessel dilations and it also mitigates Nitric Oxide. Nitric Oxide Cialis and Viagra have Nitric Oxide and it relaxes blood vessels and opens them up.
phosphodiesterase type 5 – this could be the reason that we don’t feel blood moving in our penis and why it is always cold.
https://www.cmtmedical.com/mens-sexual-health-use-penis-pump/
phosphodiesterase type 5 mitigating Nitric Oxide and causing low blood movement by contracting blood vessels is the reason for fibroses of penis.
“The lack of free oxygen, transported to the penis by hemoglobin is theoretically detrimental to the synthesis of Nitric Oxide. Corporal hypoxia predisposes the penis to cavernous fibrosis.”
Penis is being starved of nutrients as it doesn’t have nocturnal erections/erections
A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, for instance a bond in a molecule of cyclic AMP or cyclic GMP.
An enzyme that plays an important role in the repair of oxidative DNA damage is the 3’-phosphodiesterase.
During the replication of DNA, there is a hole between the phosphates in the backbone left by DNA polymerase I. DNA ligase is able to form a phosphodiester bond between the nucleotides.