5AR is a part of cell. It is supplied under DNA direction. IT is not possible to damage DNA with a drug. All our problems come from the inflamation caused by the drugs we used permanently. When particular organ, most propably liver or prostate (or both) get inflammed, then enzymatic down regulation appears and there are general problems with your health concerning many aspects.
If you will fight inflammation, that you may not even realize you have, you will propably return to normality.
If drug like Finasteride or Dutasteride could cause DNA damage/cellular damage it could not be sold.
If you pop chemical pills you may expect with a high propability that after years or months your body will tell you- enough.
If it will do so, then you should find the inflammation that have caused the cascade of other negative feedbacks.
I bet it is the prostate, and if you pop your pills further then it might be the liver problem or both.