Effect of Fixed Oil of Nigella Sativa on Male Fertility in Normal and Hyperlipidemic Rats
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RESULTS
Lipid profile: Feeding of male rats a diet containing 1% Cholesterol significantly (p<0.01) increased total cholesterol, triglycerides (Table 1) and LDL (Table 2) levels in plasma. On the other hand, HDL level (Table 2) decreased significantly (p<0.01) as compared to those fed the basal diet.
Oral administration of oil of Nigella sativa to normal rats caused a significant decrease (p<0.01) in Cholesterol, triglycerides and LDL levels as compared to control -ve, 2 months post administration and a significant increase (p<0.01) in HDL level.
The treatment of hyperlipidemic rats with the oil led to a significant decrease (p<0.01) of previous parameters except HDL which elevated significantly at 1 and 2 months post treatment as compared to control +ve
Weights of sex organs: The weights of testes and seminal vesicles of hyperlipidemic control rats decreased significantly (p<0.01) 2 months post treatment (Table 3) as compared to normal control.
Normal rats given oil of N. sativa showed a significant (p<0.01) increase in seminal vesicle weight at all time intervals, while the weights of testes and epididymis didn’t change significantly. Hyperlipidemic rats treated with N. sativa oil showed increase in seminal vesicles (p<0.01) weight at all time intervals and in testes weight at 2 months post treatment as compared to control +ve.
Testosterone Level: Plasma testoterone level (Fig. 1) of hyperlipidemic control rats (control +ve) exhibited a significant decrease (p<0.01) at all time intervals as compared to normal control.
The hormone level elevated significantly (p<0.01) in normal or hyperlipidemic rats treated with oil of N. sativa as compared to corresponding control at any time interval.