Calling for Study Participants for First Molecular Level PFS Study EVER ********************

[Mew]

If our hypothesis doesn’t verify, then we’re up sh** creek, because there will be no alternative hypothesis which even comes close to explaining everything as well as the current one does.

Here I must disagree, slightly.

The skin biopsies that were taken are being stored in such a fashion that multiple tests can be run on them, if nothing turns up in the initial investigation.

There are other areas that could be investigated using the samples from those men who have participated. For example (and I know Awor has a difference of opinion here ), looking at 5AR2 gene expression or enzyme function, or other metabolic pathways/processes.

However, looking at these alternative areas would only be required if nothing turns up in the initial investigations. Therefore, we must wait and see what results emerge, before we can assess what next steps will be.

[awor]

@Mew

The skin biopsies that were taken are being stored in such a fashion that multiple tests can be run on them, if nothing turns up in the initial investigation.

There are other areas that could be investigated using the samples from those men who have participated. For example (and I know Awor has a difference of opinion here ), looking at 5AR2 gene expression or enzyme function, or other metabolic pathways/processes.

The preparation of the cells has been done in such a way to support the planned experiments. It is not possible to investigate enzyme function, pathways or processes with the current samples (because the requirements of static vs. dynamic experiments are not the same). We would need new samples for that (and possibly other cell type) and would have to culture them accordingly, specifically geared to the types of experiments you are mentioning. The only thing from your list that we could investigate is SRD5A2 gene expression. I doubt though, if this fails, that 5AR2 will be the next path of investigation.

[Oscar]

@awor

The only thing from your list that we could investigate is SRD5A2 gene expression. I doubt though, if this fails, that 5AR2 will be the next path of investigation.

Or what about testing the ‘gene expression’ for the four 3aHSD isoforms that actually produce 3aDiol? Surely checking all the enzymes that go into producing 3aDiol is logical.

[moonman1]

@Oscar

@awor

The only thing from your list that we could investigate is SRD5A2 gene expression. I doubt though, if this fails, that 5AR2 will be the next path of investigation.

Or what about testing the ‘gene expression’ for the four 3aHSD isoforms that actually produce 3aDiol? Surely checking all the enzymes that go into producing 3aDiol is logical.

Yup, logically the three 5ar isoforms (especially 2 and 3) and the three 3aHSD isoforms should be checked as well as androgen receptor insensitivity.

[damielmillo]

Thank Awor and other members for your work…i am from Argentina, and here, and Brazil there are a lot of PFS sufferers…
If we can help in anything please tell us…
Wait for news in September…please God help us… This poison has really kill my life…
Thanks

[tim1911]

Mew and awor is there anything in the works to get anyone tested for allopregnenalone and thdoc? And do you see the point in this?

Thanks

[bluecloud87]

When do we find out the results on this study?

[tim1911]

@UK20

When do we find out the results on this study?

Have you read this thread?

[bluecloud87]

I had indeed but missed where Awor said that results will be out by late September.

[Lincoln28]

@UK20

I had indeed but missed where Awor said that results will be out by late September.

Mid september.

[Luckfax]

@Seanyboy01

@UK20

I had indeed but missed where Awor said that results will be out by late September.

Mid september.

Maybe we should have a countdown clock until the time of the announcement?

I dread to think what will happen if the hypothesis isn’t supported. This place will become awash with shit theories.

[Lincoln28]

@Luckfax

@Seanyboy01

@UK20

I had indeed but missed where Awor said that results will be out by late September.

Mid september.

Maybe we should have a countdown clock until the time of the announcement?

I dread to think what will happen if the hypothesis isn’t supported. This place will become awash with shit theories.

Im dreading the result, either way.

[fin2005]

Its progress either way. Even if it shows that his hypothesis was wrong, at least it eliminates that theory and we can move on to other avenues without just guessing and debating on a forum. This will be solid scientific backed evidence. Thanks again to all who organized and participated, I’m looking forward to the results. Ditto on the countdown clock, put it at the top of the homepage

[boston332]

I guess like everyone else I can’t help but consider what life could be like again to be my old self. I’d like to imagine a miracle. Today’s my birthday and I’ve seen another year pass me by being completely screwed up from Fin. I’m not expert at all but I think Awor is on the right track here. This is really the only theory that explains the crash event. I’m still waiting to hear how prostatitis can shrink my penis by 50% overnight.

Let’s not worry about countdowns. Let’s all just participate fully and pray…

[Lincoln28]

@boston332

I guess like everyone else I can’t help but consider what life would be like again to be my old self. I’d like to imagine a miracle. Today’s my birthday and I’ve seen another year pass me by being completely screwed up from Fin. I’m not expert at all but I think Awor is on the right track here. One big factor here is this is really the only theory that explains the crash event. I’m still waiting to hear how prostatitis can shrink my penis by 50% overnight.

Let’s not worry about countdowns. Let’s all just participate fully and pray…

If the tests come back positive, tehn what would the treamnet options be? Apoplogies if this has been covered.

And, Happy Birthday. You should try to take today away from this site.

[toadstool]

@boston332

I guess like everyone else I can’t help but consider what life would be like again to be my old self. I’d like to imagine a miracle. Today’s my birthday and I’ve seen another year pass me by being completely screwed up from Fin. I’m not expert at all but I think Awor is on the right track here. One big factor here is this is really the only theory that explains the crash event. I’m still waiting to hear how prostatitis can shrink my penis by 50% overnight.

Let’s not worry about countdowns. Let’s all just participate fully and pray…

Theres been plenty of ppl who have reported increased over night size in their penis from certain remedies… wouldnt you say thats very similar…

btw: Happy Birthday…

[boston332]

I’ve really had no relief from the shrinkage and I’ve pretty much tried everything under the sun except a course of antibiotics.

Not to speak for Awor but I think he said possible treatments fall under the currently confidential category. I believe that will depend if the problem in the signal is where he/they suspect. He said they do have something in mind, which is somewhat encouraging.

ps- thanks for the bday wishes.

[BP7667]

My penis returns to normal size with T3 and lowered cortisol, usually between 6pm and 1-2am my penis is about normal size again. My testicles on the other hand… do not flucuate in size so much.

[Lincoln28]

@Broken_Pecker

My penis returns to normal size with T3 and lowered cortisol, usually between 6pm and 1-2am my penis is about normal size again. My testicles on the other hand… do not flucuate in size so much.

My testicles get smaller between 2AM AND 9AM. Mostly the early hours of the morning.

[golf]

@Seanyboy01

@Broken_Pecker

My penis returns to normal size with T3 and lowered cortisol, usually between 6pm and 1-2am my penis is about normal size again. My testicles on the other hand… do not flucuate in size so much.

My testicles get smaller between 2AM AND 9AM. Mostly the early hours of the morning.

Please keep this thread on topic. Thanks.