Calling for Study Participants for First Molecular Level PFS Study EVER ********************

Science PFS Research
#541

Does anyone have the details of this study? Specifically, the results/discussion of the blood-work. Thanks!

“Clinical analysis in young patient with persistent sexual dysfunctions after finasteride assumption to prevent male pattern hair loss”

Trombetta C.1, Mazzon G.1, Liguori G.1, Ollandini G.1, Cauci S.2,
Toffoli G.3, Erika E.4

INTRODUCTION & OBJECTIVES: Finasteride is commonly used to
treat male pattern hair loss (MPHL). The effectiveness of the drug has
been demonstrated in a number of studies. Finasteride has been
associated with reversible adverse sexual side effects in multiple
randomized, controlled trials. The mentioned side effects are described
as reversible. However in literature a lot of case of persistent sexual
adverse symptoms are signaled. The persistence of symptoms after
discontinuation is named Post-Finasteride Syndrome (PFS). We
sought to characterize the types and duration of persistent sexual side
effects in otherwise healthy men who took finasteride for MPHL.

MATERIAL & METHODS: We enrolled in a retrospective study 78
patients affected by PFS who reported the new onset of sexual side
effects associated with the temporal use of finasteride, in which the
symptoms persisted for at least 3 months despite the discontinuation of
finasteride. Of all patients were collected hormonal blood analysis,
moreover to all the patients were dispensed ASEX and AMS
questionnaires before and after finasteride use. The blood analysis
need to have been performed not longer than 9 months before entering
the study and after 3 months of abstinence from any exogenous
hormonal/antidepressive/antipsychotic treatments or anabolic
androgenic steroids. Moreover, all patients with other diseases were
excluded.

RESULTS: Patients were aged 24-56. ASEX evaluated before and
after finasteride assumption had a mean decreasing of 13,84 (P<0.05).
No statistically significant differences were observed in relation to the
duration of therapy or to the age of assumption. 60% of patients
reported that their symptoms worsened after discontinuation of the
drug.

CONCLUSIONS: The finasteride used in young males should
determine a potential risk for sexual health, physicians treating MPHL
should evaluate the potential risk of persistent sexual side effects
associated with finasteride.

#542

I have met some guys who are being treated by Dr.Irwig the way he is treating ( hormones, clomid etc the same failed stretgy ) looks like he did not grasp the nature of the problem very well. He thinks it is hormonal issue only.
It is very disappointing many people here and many doctors think we have a non-functioning cock, that is it.
The only way the sides can be understood very well is when some specialist tries this medicines on him self.

#543

I think Irwig is likely doing what everyone else is doing which is trying to treat the side effects with the only tools he has at the moment. No one right now understands the root problem or is having any success with treatment.

Back on topic- Any updates at all here? Seems very quiet lately.

#544

I am confused. When I spoke to Irwig over the phone, he told me I should NOT use hormones etc. because they do not seem to have any beneficial or lasting effect. Now he is treating others with hormones and clomid etc. ? This was not my experience when speaking to him, at all.

#545

Don’t listen to spstricken

#546

While I understand the anxious anticipation of the release of the study, it might make sense if we all try to be a little more patient. The moderators have been pretty good about keeping us informed as best they can, but unfortunately the research process is inherently very political and the premature release of information could be counterproductive.

#547

Completely understand not prematurely releasing information, just wondering why there has really been no discussion at all here. Hoping things are still well on track.

Those members in Isreal might want to drop this guy an email. Interesting video here (part 2 of a series on epigenetics) on DNA methylation. youtube.com/watch?v=DsTfQHMf7XY

#548

I see Dr. Irwig every few months since I work a few blocks away from him. I don’t think he is viewing the problem as strictly hormonal as he never recommended Clomid or test to me. He has always viewed my results as “in range.” He did prescribe me Clomid but only because I asked him too. He mentioned that from his experience, Clomid would likely not help me at all and he was right.

#549

I’m not really worried by the lack of new information. I totally understand that finalizing the study, having it peer-reviewed and ready for publishing etc. is a very long process. I’m only worried that awor hasn’t logged in in over a month. I hope he is okay and just very busy.

#550

He may not have logged in but he’s around, I’ve spoken to him via email and Skype about unrelated matters.

#551

How about any related matters.any good news or help coming up.anything that can bring us some hope.there hasn’t been anything positive on here in over a month.that’s why we are all worried about awor and any progress.

#552

Guys should go on with their lives. The day the study is published will be a big step forward, but there’s no treatment that will be available for a while.

#553

Much easier said then done, for many of us on here including myself, this has pretty much put our lives on hold.

#554

Thanks for the clarification! Good to hear (read)!

I know it’s frustrating, but one month really is nothing in a project like this. From what I read the original idea of testing genital tissue on the molecular level was developed around 2009 or so. So it took around 3 years just to get this going. I imagine there multiple scientists involved who are not working for this project exclusively, lab time has to be booked, special equipment has to be booked, things have to be coordinated, the results have be interpreted, the article has to be written, reviewed by the team, peer reviewed by other scientist and a lot more. This and coordinating all this takes a lot of time.

As frustrating as it is, things won’t develop at a monthly rate. So I’ve to agree that we have to go one with our lives. This is important work, but a cure won’t be around the corner. Use the time inbetween to do what you can do on your own. Improve your lifestyle, treat your symptoms and try to live your life as good as you can.

#555

I really think - doing a study is a very good think. But can´t we do something more? It is about 2000 members in this forum, if we collect 50 bucks per month - this is 100.000 per month - we could do a lot with this money. What do you think?

If we would use a network of scientist - we need some power and this is money…

Any ideas?

#556

Apparently we are due big news concerning this situation in the very near future.

Can anyone clarify if this ‘big news’ is still due this month?

#557

what does this mean? News about a treatment? Or news about building a network? or about the study in this topic?

#558

Well apparently time has no meaning here.

#559

I just want to repeat the idea. What about collecting money and start more research - researchers don´t give a fuck searching a treatment. As long as they don´t benefit on it.

Could anybody please respond to this message?

#560

This has brought up numerous times in the past year. Mew stated that he is working on it, but again…gives coded answers lately anytime asks about it. It shouldnt be that hard to set up if someone knows the legal process. We could easily have had a couple hundred thousand in it by now if it would have been set up last year.

My only concern is in the one person who sets it up, are they just going to use it however they see fit, are they going to allow the researchers to use it how they see fit, or are they going to allow the contributors to vote?