On a similar note, this Japanese hair-loss blog also goes into detail about PFS, complete with a link to the PFS Foundation:
agablog.tokyo/minoxidil-finasteride/106
Below is an English translation, which isn’t great, but at least gives you an idea of how the Japanese (who, as Pearl Harbor showed us, can be very vindictive) are handling this issue.
Note to Kenneth C. Frazier: The cat is way, way, WAY out of the bag at this point. There is no going back to sweeping the finasteride fiasco under the rug. So remember two names from this day on:
(1) Richard Nixon
(2) Bill Cosby
Just in case you didn’t hear me the first time, here they are again:
(1) Richard Nixon
(2) Bill Cosby
AGA treatment doctors think seriously
AGA, for the correct knowledge and the latest treatment of alopecia
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Focusing on finasteride side effects post finasteride syndrome
In alopecia treatment Although it is finasteride, which is taken in most men worldwide (Propecia), post-marketing, side effects were observed in clinical trials have been reported. It is the post-finasteride syndrome (post finasteride syndrome). In to happen (or continued) words that represent collectively the symptoms after you have finished drinking the literal translation is as finasteride, America is is raised post-finasteride syndrome Foundation (The post-finasteride syndrome foundation), Study on the after-effects of finasteride side effects It will have been made.
Side effects of oral of Propecia, is a place where well-known include decreased libido and impotence. Most of the oral medicine is so, but because it is a liver metabolism, Propecia is also can cause liver dysfunction, the frequency is not high. Also, if there is a drug-specific allergies, rashes, hives, but there is a possibility that happen allergic symptoms such as angioedema, which is also the frequency is not high. However, side effects in the genital area as small as difficult to say, the libido has been known to occur at a rate across 1% to 5% of. It does not take accurate statistics, but in the sense of actual clinicians, the proportion of patients who feel the libido fell, it feels like more often. What is reported in the genital-related side effects, in addition to decreased libido, erectile dysfunction, ejaculation disorder, decreased semen volume, a decrease in sperm concentration, decreased sperm motility, sperm dysfunction, male infertility, testicular pain, etc. It is. Besides, breast pain and breast enlargement (gynecomastia), depressive symptoms, dizziness, have been reported liver spots. There also occur report of male breast cancer, but it does not clear the cause-and-effect relationship was observed. In addition, occurrence reports of high-grade prostate cancer (relative risk 1.70 [95% confidence interval: 1.23-2.34]) there is.
Many of the side effects, it is believed to promptly recover after taking discontinuation, are reported cases that do not improve the symptoms of side effects even if you stop taking the drug, but it has been referred to as the post-finasteride syndrome at the beginning. That especially has become a problem in the, decreased libido, erectile dysfunction, and sexual function-related side effects such as ejaculatory disorders, is the mental side effect of depressive symptoms. Papers relating to the post-finasteride syndrome, although not yet a lot out, we will introduce some.
◯ Incomplete Recovery of Erectile Function in Rat After Discontinuation of Dual 5-alpha Reductase Inhibitor Therapy. [J Sex Med 2012 Jul; 9 (7):. 1773-81]
Dutasteride (and later again in this regard, but the drug is having the same mechanism of action and finasteride) was administered for 8 weeks in the mouse, also not fully recovered after discontinuation erectile function (corpora cavernosa relaxation) failure It is reported that. The dose is 0.5mg / day, due to the use of quite a large number than people, this results Although it is unlikely that immediately lead to people, recovery of erectile function in spite of the short-term administration of 8 weeks It should be noted that but you are prolonged.
◯ Persistent sexual side effects of finasteride for male pattern hair loss. [J Sex Med. 2011]
To healthy male 71 people from 21 years old who were taking finasteride in the past 46 years old, after taking before taking finasteride for sexual disorders (after discontinuation) is a paper that was scored in an interview format . Finasteride average taking period of men in the 28-month period, the average period from discontinued finasteride until this interview study is 40 months. Despite or more has elapsed after discontinuation average three years, decreased libido in 94% of subjects, a decrease in erectile dysfunction and sexual arousal in 92%, and resulted in feels orgasm abnormal in 69% It has. A greater or lesser extent, this is a very high number. Of course, and it is an interview format with retrospective investigation, until the before and after discontinuation in the investigation taking place, because the Years of five years to six years on average is flowing, it is true that the lack of accuracy as the investigation . Decreased libido, it might also think that or not aging phenomenon also some of due date, also the result must take seriously.
In addition, it is Review (summarizes the past paper format), but depression in addition to sexual function, mood disorders, paper summarizing and cognitive dysfunction has come out. (I also do not read the full text, introduction only)
◯ Review Adverse side effects of 5α-reductase inhibitors therapy:. Persistent diminished libido and erectile dysfunction and depression in a subset of patients [. J Sex Med 2011]
◯ Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride:. A Survey of Men Reporting Symptoms [. Am J Mens Health 2014 Jun 13.]
That the United Kingdom and Switzerland of the Medicines Control Agency (Food and Drug Administration) that is likely to persist for early sexual dysfunction, is instructed as described in the leaflet to be passed to patients, the American FDA (Food and Drug Administration late ) also ED symptoms to note products, erectile dysfunction, it was requested to pharmaceutical companies to add a ejaculation failure. In Japan, erectile dysfunction, ejaculation disorder, libido (sexual desire) has the phrase “after discontinuation administration also has been reported to have sustained” is added to three of decline.
With regard to depression, that there is a possibility of sustained notes are not listed. However, depressive symptoms that persist after discontinuation, there are several reports. Because the sexual desire and mental state has been involved in very closely, reported but not a so all, the proportion is a side effect of finasteride I hope to considerably or not high for the. The mechanism has been reported, such as reduction of neurosteroids in the brain caused by finasteride (neurosteroids), but details are not known.
