Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model


Interesting study which was done. ‘Pre-treatment with finasteride, a synthetic ALLO inhibitor, suppressed ethanol-induced scratching and ALLO production in the brain. Collectively, our results demonstrated for the first time that ALLO administration caused marked scratching in atopic dermatitis mice, and ethanol-induced scratching may be mediated through endogenously produced brain ALLO.’

This could explain why PFS sufferers have noticed changes in their dermatitis, if a depletion of allopregnanolone is the cause.